59724-80-0Relevant academic research and scientific papers
Design, synthesis of new chiral fluorine-containing β-hydroxysulfonamides from natural amino acids and study of their anti-inflammatory and analgesic activities
Gloulou, Monia,Kra?em, Jamil,Jennene, Fay?al,Ghedira, Donia,Amor, Haifa Bel Haj,Lajili, Sirine,Jalleli, Emna,Ferjani, Maha,Bouraoui, Abderrahman,Kallel, Mohamed
, p. 1497 - 1506 (2016/07/06)
A series of new chiral fluorine-containing β-hydroxysulfonamides were conveniently synthesized in three steps, starting from natural L-amino acids, and evaluated for their anti-inflammatory and analgesic activities. The structures of these compounds were supported by FT-IR, 1H, 13C and 19F NMR, elemental analysis and HRMS. Among the tested compounds, 4c, 4g and 4h exhibited promising anti-inflammatory activity. Moreover, compound 4h showed a significant analgesic activity. The structure–activity relationships of selected compounds were discussed.
Efficient synthesis of new imidazo[1,2-b][1,2]benzothiazine 4,4-dioxide derivatives via lateral lithiation of N-mesitylenesulfonyl hydantoins
Kacem, Yakdhane,Ben Hassine, Béchir
, p. 5608 - 5610 (2012/10/29)
N-Mesitylenesulfonyl hydantoins, readily available from commercial α-amino acids, undergo lateral lithiation with an excess of lithium diisopropylamide and tetramethylethylenediamine in the presence of trimethylsilyl chloride to provide new imidazo[1,2-b]
A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2 + 2] cycloaddition of allenes
Ohno, Hiroaki,Mizutani, Tsuyoshi,Kadoh, Yoichi,Aso, Akimasa,Miyamura, Kumiko,Fujii, Nobutaka,Tanaka, Tetsuaki
, p. 4378 - 4389 (2008/02/05)
(Chemical Equation Presented) Thermal [2 + 2] cycloaddition of allenes with an additional multiple bond is described. By simply heating the allenenes or allenynes having a three-atom tether in an appropriate solvent such as dioxane or DMF, the distal doub
