59729-31-6 Usage
Originator
Remivox,Janssen,W. Germany,1980
Uses
Cardiac depressant (anti-arrhythmic).
Manufacturing Process
To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane
is added and stirring and refluxing is continued for another 19 hours. The
reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily
free base, the hydrochloride salt is prepared in the conventional manner in
1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off
and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2
parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]
benzeneacetamide hydrochloride; melting point 263°C.
Therapeutic Function
Antiarrhythmic
Check Digit Verification of cas no
The CAS Registry Mumber 59729-31-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,7,2 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 59729-31:
(7*5)+(6*9)+(5*7)+(4*2)+(3*9)+(2*3)+(1*1)=166
166 % 10 = 6
So 59729-31-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3
59729-31-6Relevant articles and documents
N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
-
, (2008/06/13)
Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as anti-arrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.
