59747-91-0Relevant academic research and scientific papers
1-ARYLOXY-4-AMINO-2-BUTANOLS AND THE PHARMACEUTICAL USE THEREOF
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, (2008/06/13)
Novel 1-aryloxy-4-amino-2-butanols of the formula EQU1 wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R 1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R 2 is hydrogen or lower alkyl, wherein R 1 and R 2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.
