59749-65-4Relevant articles and documents
CONFORMATIONAL EQUILIBRIUM AND VIBRATIONAL SPECTRA OF 2-ISOCYANO ETHYLCYANIDE
Schrumpf, G.,Martin, S.
, p. 57 - 68 (1983)
The infrared spectra of 2-isocyano ethylcyanide as a liquid, a polycrystalline solid and in apolar solvents have been measured.Raman spectra were recorded for the liquid.The data were interpreted in terms of an equilibrium between trans and gauche rotamers.In the liquid, both conformers are present, while in the solid only the gauche conformer was found.Apolar solvents favour the trans rotamer.A complete vibrational assignment has been proposed for both conformers and discussed with respect to the assigned spectra of related molecules.
Synthesis method of formyl pyrimidine
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Paragraph 0078-0091, (2020/07/03)
The invention discloses a synthesis method of formyl pyrimidine, which comprises the following steps: (1) by using formamide and acrylonitrile as raw materials, carrying out Michael addition reactionunder the action of a catalyst A and post-treatment to obtain 3-formamide propionitrile; (2) by taking 3-formamido propionitrile and paraformaldehyde as raw materials, carrying out condensation reaction in the presence of a catalyst B and a benzene solvent, and carrying out post-treatment to obtain N-(2-cyanovinyl)-formamide; and (3) with N-(2-cyanovinyl)-formamide and free acetamidine as raw materials, carrying out a condensation reaction in a low-grade fatty alcohol solvent, then heating, carrying out oxidative aromatization under the action of a catalyst C, and finally, carrying out post-treatment to obtain formyl pyrimidine. The synthesis method disclosed by the invention has the advantages that the route is green, safe and environment-friendly; and an activating group and a leaving group are not adopted, so that the atom economy of the reaction is high.
One-step ring preparation of 2-methyl-4-amino-5-amino methyl pyrimidine convenient synthetic method
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Paragraph 0038-0040, (2017/03/08)
The invention relates to a portable synthesis method for preparing 2-methyl-4-amino-5-aminoethylpyrimidine through one-step cyclization reaction. The method comprises the following steps: directly catalyzing acetamidine hydrochloride and 3-acyl aminopropionitrile to condense and to react with triester orthoformate for dealcoholization and cyclization by using lewis acid, and then hydrolyzing to obtain a vitamin B1 key intermediate, namely the 2-methyl-4-amino-5-aminoethylpyrimidine. According to the method disclosed by the invention, the raw materials are low in cost and easily obtained, and no sodium alcoholate needs to be used for dissociating acetamidine hydrochloride, thus the decomposition of acetamidine is reduced, and the high yield is achieved through reaction; the cyclization and hydrolysis reactions are sequentially carried out, products in all steps are not required to be separated and purified, and the synthesis method is simple and convenient to operate. Highly carcinogenic o-chloroaniline or other micromolecular aniline compounds are not used, and the portable synthesis method is environment-friendly in process, free of production of wastewater and beneficial to industrial production.