597543-91-4Relevant academic research and scientific papers
6,7-Dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-Like growth factor (IGF) to IGF-binding proteins: Optimization of the 1-position benzoyl side chain
Zhu, Yun-Fei,Wilcoxen, Keith,Gross, Timothy,Connors, Patrick,Strack, Nathalie,Gross, Raymond,Huang, Charles Q.,McCarthy, James R.,Xie, Qiu,Ling, Nicholas,Chen, Chen
, p. 1927 - 1930 (2003)
A series of 1-benzoyl isoquinolines, based on compound 1, was synthesized and evaluated for their ability to displace IGF-I from its complex with IGF-binding protein-3. Successful modifications of 1 included the replacement of the 3,4-dihydroxybenzoyl gro
