597556-89-3

Upstream product

• 64741-13-5 3-thiophenyl-3-sulfolene 
• 4083-64-1 Tosyl isocyanate 
• 110026-88-5 2-Allyl-4-phenylsulfanyl-2,5-dihydro-thiophene 1,1-dioxide 

Downstream Products

• 1370413-52-7 6-allyl-4-(phenylsulfonyl)-1-tosyl-5,6-dihydropyridin-2(1H)-one 
• 1415683-60-1 4-(phenylthio)-6-(E-1-propenyl)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 1415683-66-7 7-(phenylsulfonyl)-3,5,8,8a-tetrahydro-5-indolizinone 
• 1415683-65-6 2-methyl-7-(phenylthio)-3,5,8,8a-tetrahydro-5-indolizinone 
• 1415683-64-5 7-(phenylthio)-3,5,8,8a-tetrahydro-5-indolizinone 
• 1415683-63-4 1-(2-methylallyl)-4-(phenylthio)-6-(E-1-propenyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 1415683-62-3 1-allyl-4-(phenylthio)-6-(E-1-propenyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 1415683-61-2 4-(phenylthio)-6-(E-1-propenyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 1370413-56-1 6-allyl-4-(4-methoxycarbonyl-1H-1,2,3-triazol-1-yl)-1-tosyl-5,6-dihydropyridin-2(1H)-one 
• 949103-81-5 2-(phenylthio)-1,6,9,9a-tetrahydroquinolizin-4-one 
• 949103-88-2 6-allyl-1-(2-methylprop-2-enyl)-4-(phenylthio)-1,2,5,6-tetrahydropyridin-2-one 
• 949103-87-1 6-allyl-1-(but-3-enyl)-4-(phenylthio)-1,2,5,6-tetrahydropyridin-2-one 
• 949103-80-4 1,6-diallyl-4-(phenylthio)-1,2,5,6-tetrahydropyridin-2-one 
• 597556-85-9 6-allyl-4-(phenylthio)-1,2,5,6-tetrahydropyridin-2-one 

Relevant academic research and scientific papers

Synthesis of sulfur-substituted quinolizidines and pyrido[1,2-a]azepines by ring-closing metathesis

Sulfur-substituted quinolizidines and pyrido[1,2-a]azepines (7) can be prepared by ring-closing metathesis (RCM) of 4-(phenylthio)-1,2,5,6-tetrahydropyridin-2-ones (6) bearing terminal alkenyl groups at both N-1 and C-6 positions, which are obtained from 3-(phenylthio)-3-sulfolene (1) in four steps. Some synthetic transformations of 2-(phenylthio)-1,6,9,9a-tetrahydroquinolizin-4-one (7a) and 2-(phenylthio)-1,6,9,10,10a-pentahydropyrido[1,2-a]azepin-4-one (7d) are also reported.

Synthesis of 6-substituted tetrahydropyridinones and cyclization to indolizidine and quinolizidine structures

3-Sulfolenes 1 with various substituents at C-2 underwent [4+2] cycloaddition reactions with p-toluenesulfonyl isocyanate to give the teterahydropyridinones 4. Through N-detosylation and Hg(II)-mediated electrophilic addition/intramolecular cyclization of