597559-63-2Relevant academic research and scientific papers
Novel syntheses of the amino-1,2,4-triazine GW356194: Identification of a synthesis amenable to scale up
Adam, Fiona M.,Burton, Andrew J.,Cardwell, Kevin S.,Cox, Richard A.,Henson, Richard A.,Mills, Keith,Prodger, Jeremy C.,Schilling, Mark B.,Tape, Daniel T.
, p. 5657 - 5659 (2003)
New syntheses of the amino-1,2,4-triazine, GW356194 have been developed to improve on existing methodology. The use of different amidrazones in cyclisations with α-keto and α-amido carbonyl compounds as the key step for the synthesis of the 1,2,4-triazine core was evaluated and the results are presented here.
