59757-38-9

Upstream product

• 19212-27-2 3-oxo-4-phenylbutyronitrile 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1228383-86-5 4-benzyl-4'-isobutyl-2'-phenyl-2,5'-bipyrimidine-5-carbonitrile 
• 1228383-91-2 2'-amino-4-benzyl-4'-isobutyl-2,5'-bipyrimidine-5-carbonitrile 
• 1228383-76-3 4-benzyl-2-methylpyrimidine-5-carbonitrile 
• 1228383-71-8 2-amino-4-benzylpyrimidine-5-carbonitrile 
• 1228383-79-6 4-benzyl-2-phenylpyrimidine-5-carbonitrile 
• 1228383-75-2 4-benzylpyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLD

Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domain. The new scaffold is easier to make than previous scaffolds and has much more favorable physical properties than previous alpha-helix mimics. The amphiphilic alpha-helix mimetics have application for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.