597584-72-0

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-[2-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 597584-72-0
• Molecular Formula: C16H21F3N2O5S
• Molecular Weight: 410.414
• Mol File: 597584-72-0.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-[2-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-[2-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-, 1,1-dimethylethyl ester(597584-72-0)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-[2-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-, 1,1-dimethylethyl ester(597584-72-0)

Safety Data

• Hazardous Substances Data: 597584-72-0(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 313657-51-1 tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate 

Downstream Products

• 597584-73-1 tert-butyl 4-[3'-(1-{[(cyanomethyl)amino]carbonyl}-3-methylbutyl)-1,1'-biphenyl-2-yl]piperazine-1-carboxylate 

Relevant articles and documents

1,2-Di(cyclic)substituted benzene compounds

In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.