59770-94-4Relevant academic research and scientific papers
DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation-Hydrogenolysis Strategy of Enaminones
Borah, Ashwini,Goswami, Limi,Neog, Kashmiri,Gogoi, Pranjal
, p. 4722 - 4728 (2015/05/13)
A novel heterogeneous catalytic hydrogenation-hydrogenolysis strategy has been developed for the α-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to α-methylated ketones using a variety of ketones without any base or oxidant. (Chemical Equation Presented).
4-(Benzoylindolizinyl)butyric acids; novel nonsteroidal inhibitors of steroid 5α-reductase. III
Sawada,Okada,Kuroda,Watanabe,Sawada,Tanaka
, p. 799 - 813 (2007/10/03)
A novel series of indolizinebutyric acids with various benzoyl substituents was synthesized to develop nonsteroidal inhibitors of steroid 5α-reductase, and the structure-activity relationships in this series were studied. We previously reported the structure-activity relationships in a series of indolebutyric acids as well as the discovery of the novel nonsteroidal 5α-reductase inhibitor, FK143. We have now made other modifications to this compound to improve in vivo inhibitory activity. By altering the heterocyclic nucleus and changing the benzoyl substituent we have succeeded in identifying the strongly active compound, FK687, (S)-4-[1-[4-[[1-(4-isobutylphenyl)butyl]oxy]benzoyl]indolizin-3-yllbutyric acid, which displays strong in vitro inhibitory activity against the human enzyme and in vivo inhibitory activity against the castrated young rat model. This compound should be a useful agent for the treatment of benign prostatic hyperplasia.
A new convenient reduction of aralkyl ketones to alcohols using Raney nickel-ammonium formate
Chen,Zhang,Yuan,Zhang
, p. 107 - 109 (2007/10/02)
Various aralkyl ketones have been reduced to their corresponding alcohols in high yield using Raney Ni-HCO2NH4.
