59772-71-3

Upstream product

• 59772-70-2 2-fluoro-N-[2-hydroxy-3-(methylphenylamino)propyl]benzamide 

Downstream Products

• 103379-94-8 2-chloromethyl-5-(2'-fluorophenyl)-1H-2,3-dihydro-1,4-benzodiazepine 
• 103379-92-6 2-Chloromethyl-5-(2-fluoro-phenyl)-7-nitro-2,3-dihydro-1H-benzo[e][1,4]diazepine 
• 103379-91-5 9-nitro-2-chloromethyl-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine 
• 103379-99-3 6-bromo-4-(2'-fluorophenyl)-1a,2-dihydro-1H-azirino(1,2-a)-1,4-benzodiazepine 
• 103379-98-2 7-bromo-2-chloromethyl-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine 
• 103379-95-9 1-acetyl-2-chloromethyl-5-(2'-fluorophenyl)-1H-2,3-dihydro-1,4-benzodiazepine 
• 103380-02-5 Acetic acid 7-bromo-5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl ester 
• 103379-97-1 2-hydroxymethyl-5-(2'-fluoro-5'-nitrophenyl)-1H-2,3-dihydro-1,4-benzodiazepine 
• 103379-96-0 1-acetyl-2-chloromethyl-5-(2'-fluoro-5'-nitrophenyl)-1H-2,3-dihydro-1,4-benzodiazepine 
• 103380-03-6 7-bromo-2-hydroxymethyl-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine 
• 103380-00-3 7-bromo-2-methoxymethyl-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine 
• 103379-93-7 7-nitro-2-hydroxymethyl-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine 
• 61677-47-2 7-bromo-5-(2-fluoro-phenyl)-2-methoxymethyl-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepine 

Relevant academic research and scientific papers

1,4-Benzodiazepine and 1,5-benzodiazocines. VII. Synthesis and biological activity

Synthesis of a new class of 2,3,-dihydro-1H-1,4-benzodiazepines and of the corresponding 1,2,3,4-tetrahydro-1,5-benzodiazocines is described. The biological activity of the compounds is evaluated in vivo by measuring their inhibition of pentetrazole induced seizures and in vitro by determining their affinity for the benzodiazepine receptor. Comparison of both tests reveals differences between activity in vivo and in vitro which are discussed.