59776-74-8Relevant academic research and scientific papers
Direct Synthesis of 5-Acyl-3-oxy-4-pyrones Based on Acid-?-Catalyzed Acylation of Enaminodiones with Acylbenzotriazoles via Soft Enolization
Chernyshova, Elena V.,Obydennov, Dmitrii L.,Shirinkin, Alexander S.,Sosnovskikh, Vyacheslav Y.,Usachev, Sergey A.,Viktorova, Viktoria V.
, p. 2267 - 2276 (2020)
A novel convenient acid-catalyzed acylation of enaminodiones with acylbenzotriazoles via soft enolization has been developed for the direct synthesis of hard-to-reach 5-acyl-3-oxy-4-pyrones. The important advantages of the reaction include broad substrate scope, mild conditions, scalability, and readily isolation of products by crystallization without the use of chromatography. Further modification of the pyrone ring and synthesis of various azaheterocycles via ring-opening transformation have been demonstrated for the preparation of potential scaffolds for inhibition of metalloenzymes.
Transformation of 1,5-diphenylpentane-1,3,5-trione. The synthesis of substituted (4H)-pyranones, pyridin-4(1H)ones and 4H-pyrano[3,2-c]pyridin-4-ones
Zupancic, Silvo,Svete, Jurij,Stanovnik, Branko
, p. 899 - 909 (2008/09/21)
1,5-Diphenylpentane-1,3,5-trione (1) was transformed by the reaction either with N,N-dimethylformamide dimethyl acetal (DMFDMA) or N,N-dimethylacetamide dimethyl acetal (DMADMA) into (N,N-dimethylamino)-methylidene derivatives 2a,b as intermediates. They
