59782-91-1

Basic information

• Product Name: 2-CHLORO-3-IODO-5-PICOLINE
• Synonyms: 2-CHLORO-3-IODO-5-PICOLINE;2-Chloro-3-iodo-5-methylpyridine
• CAS NO: 59782-91-1
• Molecular Formula: C₆H₅ClIN
• Molecular Weight: 253.46807
• Product Categories: Pyridine
• Mol File: 59782-91-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 61-63 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 284.1 °C at 760 mmHg
• Flash Point: 125.6 °C
• Appearance: /
• Density: 1.906 g/cm³
• Vapor Pressure: 0.00522mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• PKA: -0.31±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-IODO-5-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-IODO-5-PICOLINE(59782-91-1)
• EPA Substance Registry System: 2-CHLORO-3-IODO-5-PICOLINE(59782-91-1)

Safety Data

• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 59782-91-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-iodo-5-picoline is a chemical compound with the molecular formula C6H5ClIN. It is a heterocyclic organic compound that contains both chlorine and iodine atoms attached to a picoline ring. 2-Chloro-3-iodo-5-picoline is commonly used as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its unique structure and reactivity make it a valuable intermediate in the production of various compounds, including pharmaceutical drugs and crop protection chemicals. Due to its versatile nature and potential for diverse applications, 2-Chloro-3-iodo-5-picoline is an important chemical in the field of organic chemistry.

InChI:InChI=1/C6H5ClIN/c1-4-2-5(8)6(7)9-3-4/h2-3H,1H3

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 34552-13-1 3-Amino-2-chloro-5-methylpyridine 
• 211308-79-1 2-amino-3-iodo-5-methylpyridine 

Downstream Products

• 904745-62-6 3-bromomethyl-6-chloro-5-iodopyridine 
• 949587-55-7 6-chloro-5-phenylpyridin-3-ylmethyl bromide 
• 949587-54-6 2-chloro-5-methyl-3-phenylpyridine 

Relevant articles and documents

Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma

Melanin pigment represents an attractive target to address specific treatment to melanoma cells, such as cytotoxic radionuclides. However, less than half of the patients have pigmented metastases. Hence, specific marker is required to stratify this patient population before proceeding with melanin-targeted radionuclide therapy. In such a context, we developed fluorinated analogues of a previously studied melanin-targeting ligand, N-(2-diethylaminoethyl)-6-iodoquinoxaline-2-carboxamide (ICF01012). These latter can be labeled either with 18F or 131I/125I for positron emission tomography imaging (melanin-positive patient selection) and targeted radionuclide therapy purposes. Here we describe the syntheses, radiosyntheses and preclinical evaluations on melanoma-bearing mice model of several iodo- and fluoro(hetero)aromatic derivatives of the ICF01012 scaffold. After preliminary planar gamma scintigraphic and positron emission tomography imaging evaluations, [125I]- and [18F]-N-[2-(diethylamino)ethyl]-4-fluoro-3-iodobenzamides ([125I]4, [18F]4) were found to be chemically and biologically stable with quite similar tumor uptakes at 1 h p.i. (9.7 ± 2.6% ID/g and 6.8 ± 1.9% ID/g, respectively).