5979-96-4

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide is used as a potential candidate for drug development due to its ability to interact with certain receptors in the brain, which may lead to the treatment of neurological disorders.
Used in Research Applications:
(S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide is used as a valuable compound for further study in the pharmaceutical industry, particularly for its potential anti-inflammatory and analgesic properties, which may contribute to the development of new therapeutic agents.

Downstream Products

• 63828-55-7 3-carbamoyl-1-(4-methoxybenzyl)pyridinium chloride 
• 145701-21-9 N-(2,6-dichlorophenyl)-5-ethoxy-7-fluoro-1,2,4-triazolo(1,5-c)-pyrimidine-2-sulfonamide 
• 53406-00-1 3-carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride 
• 81530-72-5 2-amino-4-chloro-6-(3,4-dichlorophenyl)-s-triazine 

Relevant academic research and scientific papers

Substituted pyridine compounds and methods of use

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF- alpha , IL-1 beta , IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Hydrolysis of nitriles

Nitriles, such as acrylonitrile, are converted to the corresponding amides by a catalytic hydrolysis employing as the heterogeneous catalyst, the reaction product of a rhodium compound and a thiophosphite supported on a solid support.

Hydrolysis of nitriles

Nitriles, such as acrylonitrile, are converted to the corresponding amides by a catalytic liquid phase hydrolysis employing as the homogeneous catalyst, the reaction product of a rhodium compound and a thiophosphite.

Substituted piperidines

The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.