O-GLYCOSIDASE, also known as Endo-α-N-acetylgalactosaminidase, is a recombinant enzyme derived from Streptococcus pneumoniae and expressed in E. coli. This enzyme plays a crucial role in the hydrolysis of the unsubstituted Galβ1,3GalNAc core disaccharide, which is attached to serine or threonine residues of glycopeptides and glycoproteins. The process results in the release of free oligosaccharides. For carbohydrates containing sialic acid or fucose, pretreatment with neuraminidase or fucosidase is necessary to enhance the enzyme's efficiency.
59793-96-3
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Basic information
- Product Name: O-GLYCOSIDASE
- Synonyms: O-GLYCAN PEPTIDE HYDROLASE;O-GLYCOPEPTIDE ENDO-D-GALACTOSYL-N-ACETYL-ALPHA-GALACTOSAMINOHYDROLASE;O-GLYCOSIDASE;EC 3.2.1.97;ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE;ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE, STREPTOCOCCUS PNEUMONIAE;ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE, FROM DIPLOCOCCUS PNEUMONIAE;endo-alpha-N-Acetylgalactosaminidase (=Endo-alpha) Recombinant: from Bifidobacterium longum expressed in Escherichia coli
- CAS NO:59793-96-3
- Molecular Formula:
- Molecular Weight:
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /buffered aqueous solution
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- CAS DataBase Reference: O-GLYCOSIDASE(CAS DataBase Reference)
- NIST Chemistry Reference: O-GLYCOSIDASE(59793-96-3)
- EPA Substance Registry System: O-GLYCOSIDASE(59793-96-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 59793-96-3(Hazardous Substances Data)
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59793-96-3 Usage
Uses
Used in Pharmaceutical Industry:O-GLYCOSIDASE is used as a therapeutic agent for the treatment of various diseases, particularly those involving the malfunction or abnormality of glycoproteins. The enzyme's ability to hydrolyze specific disaccharides allows for the potential development of targeted therapies for conditions such as cancer, autoimmune disorders, and infectious diseases.
Used in Research and Development:
O-GLYCOSIDASE serves as a valuable tool in the field of glycobiology, where it is employed for the study of glycoprotein structure, function, and interactions. Researchers utilize this enzyme to investigate the role of specific glycoproteins in cellular processes and to develop a deeper understanding of the complex carbohydrate structures involved in various biological functions.
Used in Diagnostic Applications:
O-GLYCOSIDASE is used as a diagnostic tool for the detection and analysis of specific glycoproteins and glycopeptides in biological samples. The enzyme's specificity in hydrolyzing certain disaccharides enables the identification and quantification of target molecules, which can be crucial in the diagnosis and monitoring of various diseases.
Used in Drug Delivery Systems:
Similar to gallotannin, O-GLYCOSIDASE can be incorporated into novel drug delivery systems to enhance its applications and efficacy. By employing various organic and metallic nanoparticles as carriers, the enzyme's delivery, bioavailability, and therapeutic outcomes can be improved, potentially leading to more effective treatments for a range of conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 59793-96-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,7,9 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.Calculate Digit Verification of CAS Registry Number 59793-96:
(7*5)+(6*9)+(5*7)+(4*9)+(3*3)+(2*9)+(1*6)=193
193 % 10 = 3
So 59793-96-3 is a valid CAS Registry Number.
59793-96-3Upstream product
59793-96-3Downstream Products
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O-GLYCOSIDASE
