59794-92-2

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 5455-59-4 2-Nitrobenzenesulfonamide 
• 62-53-3 aniline 
• 50881-48-6 N-chlorosulfonyl-N'-phenyl-urea 
• 13338-00-6 2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide 

Downstream Products

• 57864-99-0 4-[N'-(1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carbonyl)-hydrazinosulfonyl]-benzenesulfonamide 
• 57864-98-9 3-[N'-(1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carbonyl)-hydrazinosulfonyl]-benzenesulfonamide 
• 57997-86-1 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-(4-nitro-benzenesulfonyl)-hydrazide 
• 57864-93-4 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-(4-methoxy-benzenesulfonyl)-hydrazide 
• 57864-92-3 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-(4-nitro-benzoyl)-hydrazide 
• 57864-97-8 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-(4-bromo-benzenesulfonyl)-hydrazide 
• 57864-96-7 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-(4-chloro-benzenesulfonyl)-hydrazide 
• 57864-94-5 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-(toluene-4-sulfonyl)-hydrazide 
• 57864-95-6 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-benzenesulfonyl-hydrazide 
• 59794-84-2 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid (4-hydroxy-3-methoxy-benzylidene)-hydrazide 
• 57864-91-2 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid N'-benzoyl-hydrazide 
• 59794-83-1 1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid benzylidenehydrazide 
• 57864-78-5 2H-benzo[e][1,2,4]thiadiazine-3-carboxylic acid 1,1-dioxide 
• 1025949-20-5 1,1-Dioxo-1,2-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid ((S)-1-hydroxymethyl-2-phenyl-ethyl)-amide 

Relevant academic research and scientific papers

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1- benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells

N-(2,2-Dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2, 4-benzothiadiazine-3-carboxamides 1,1-dioxides were prepared and evaluated on rat uterus, rat aortic rings and rat pancreatic β-cells. Pharmacological studies conducted on rat uterus indicated that several of these original hybrid compounds displayed a strong myorelaxant activity. The most active compounds hold a bromine atom at the 6-position of the dihydrobenzopyran ring. Moreover, the compounds failed to display a marked inhibitory effect on insulin secretion and vascular myogenic activity. These features suggest that the 6-bromo compounds could be relatively selective towards the uterine smooth muscle.

1,2-Benzothiazine 1,1-dioxide P2-P3 peptide mimetic aldehyde calpain I inhibitors

A series of peptide mimetic aldehyde inhibitors of calpain I was prepared in which the P2 and P3 amino acids were replaced by substituted 3,4-dihydro-1,2-benzothiazine-3-carboxylate 1,1-dioxides. The effect of 2, 6, and 7-benzothiazi