59797-08-9Relevant academic research and scientific papers
One or two-step Bohlmann-Rahtz heteroannulation of 6-aminouracil derivatives for the synthesis of pyrido[2,3-d]pyrimidines
Hughes, David D.,Bagley, Mark C.
, p. 1332 - 1334 (2002)
The Michael addition-cyclodehydration of a 6-aminouracil and alkynone proceeds to give 5-deazapterin derivatives with total control of regiochemistry. This simple and facile cyclocondensation process is catalyzed by zinc(II) bromide or ytterbium(III) trifluoromethanesulfonate at 110°C, providing the heteroannulated products in up to 94% yield.
Novel and facile catalytic synthesis of 2,4-dioxopyrido[2,3-d]-pyrimidine derivatives in water
Rosas,Sharma,Alvarez,Cabrera,Ramirez,Delgado,Arzoumanian
, p. 2341 - 2343 (2007/10/03)
Reactions of 6-amino-1,3-dimethyluracil with substituted α-ketoalkynes using homogeneous nickel catalyst in aqueous alkaline medium, afford substituted 2,4-dioxopyrido[2,3-d]pyrimidine derivatives in quantitative yields under very mild conditions. A mecha
