59798-30-0

Basic information

• Product Name: Mezlocillin sodium
• Synonyms: Chebi:52067;Sodium (2S,5R,6R)-3,3-dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;Sodium 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylate;Sodium 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate;Mezlocillin Sodium (350 mg);(2S,5R,6R)-3,3-DiMethyl-6-((R)-2-(3-(3-(Methylsulfonyl)-2-oxoiMidazolidine-1-carbonyl)ureido)-2-phenylacetaMido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodiuM salt;MEZLOCILLIN SODIUM;3,3-dimethyl-6-[[2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt
• CAS NO: 59798-30-0
• Molecular Formula: C21H24N5NaO8S2
• Molecular Weight: 561.56
• Product Categories: Miscellaneous
• Mol File: 59798-30-0.mol
• Article Data: 0

Chemical Properties

• Appearance: White to slightly yellow cryst. powder
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: Soluble in water or DMSO
• CAS DataBase Reference: Mezlocillin sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Mezlocillin sodium(59798-30-0)
• EPA Substance Registry System: Mezlocillin sodium(59798-30-0)

Safety Data

• Hazardous Substances Data: 59798-30-0(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
Mezlocillin sodium is used as an antimicrobial agent for treating various bacterial infections. Its effectiveness against a range of bacteria, such as B. fragilis, E. lentum, P. morbillorum, and F. nucleatum, makes it a valuable component in the development of antibiotics for medical use.
2. Used in Antimicrobial Formulations:
Mezlocillin sodium is used as an active ingredient in formulations designed to combat bacterial infections. Its ability to increase survival rates and reduce bacteremia in animal models of endocarditis and pulmonary infections highlights its potential in creating effective treatments for similar conditions in humans.
3. Used in Research and Development:
Mezlocillin sodium serves as a valuable compound for researchers studying the properties and mechanisms of β-lactam antibiotics. Its activity against specific bacteria and its role in enhancing the efficacy of conventional chemotherapeutic drugs make it an important subject for further investigation and potential development of new antimicrobial agents.

Clinical Use

Mezlocillin (Mezlin) is an acylureidopenicillin with an antibacterialspectrum similar to that of carbenicillin andticarcillin; however, there are some major differences. It ismuch more active against most Klebsiella spp., P. aeruginosa,anaerobic bacteria (e.g., Streptococcus faecalis andB. fragilis), and H. influenzae. It is recommended for thetreatment of serious infections caused by these organisms.Mezlocillin is not generally effective against β-lactamase–producing bacteria, nor is it active orally. It isavailable as a white, crystalline, water-soluble sodium saltfor injection. Solutions should be prepared freshly and, ifnot used within 24 hours, refrigerated. Mezlocillin and otheracylureidopenicillins, unlike carbenicillin, exhibit nonlinearpharmacokinetics. Peak plasma levels, half-life, and areaunder the time curve increase with increased dosage.Mezlocillin has less effect on bleeding time than carbenicillin,and it is less likely to cause hypokalemia.

InChI:InChI=1/C21H25N5O8S2.Na/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34;/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30);/q;+1/p-1