598-45-8 Usage
Uses
Used in Pharmaceutical Industry:
I-PROPYLISOCYANIDE is used as a key intermediate for the synthesis of Ugi ligand A2C11I1, which is employed in the solid-phase Ugi synthesis. This application is significant for the development of new pharmaceutical compounds and drug candidates.
Used in Polymer Industry:
I-PROPYLISOCYANIDE is used as a monomer for the preparation of Pentafluorophenyl (PFP) functional monomers via the Passerini reaction. These monomers are essential for the development of advanced polymer materials with specific properties tailored for various applications.
Used in Coordination Chemistry:
I-PROPYLISOCYANIDE is used as a building block for the synthesis of Dinuclear copper complex [Cu2(μ-PiPr2bipy)2μ-CNCH(CH3)2](PF6)2 [PiPr2bipy = 6-(diisopropylphosphanyl)-2,2′-bipyridine]. This complex has potential applications in coordination chemistry and materials science.
Used in Organic Synthesis:
I-PROPYLISOCYANIDE is used as a reactant for the preparation of (3E)-(Imino)thiaisoindoline 1,1-dioxide derivative, N,N′-diisopropylcarbodiimide (DIC) analog via reaction with propan-2-amine, 1-t-butyl-2-isopropyldiaziridinone via reaction with 2-methyl-2-nitrosopropane, and isopropyl isocyanide via reaction with ozone. These compounds have potential applications in various organic synthesis processes.
Used in Chemical Research:
I-PROPYLISOCYANIDE is used as a reactant in the synthesis of 1-phthalimidoazetidines via [1+3]cycloaddition reaction with 1-pththalimidoaziridines. This reaction is of interest to researchers in the field of chemical synthesis and material development.
Preparation
To a flask containing 100 ml (0.85 mole) of distilled quinoline is added with stirring 41 gm (0.214 mole) of /7-toluenesulfonyl chloride (see Note), and the solution is warmed to 75°C. Then 18.4 gm (0.212 mole) of isopropylformamide is added and the pressure of the system is reduced to 70 mm Hg. The isopropylisonitrile as it forms distills into a liquid nitrogencooled receiver. (Dry ice is not as effective but may be used.) The product is redistilled to afford 4.2 gm (30%), b.p. 88-89°C (735 mm Hg).
Check Digit Verification of cas no
The CAS Registry Mumber 598-45-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 598-45:
(5*5)+(4*9)+(3*8)+(2*4)+(1*5)=98
98 % 10 = 8
So 598-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N/c1-4(2)5-3/h4H,1-2H3
598-45-8Relevant academic research and scientific papers
Photochemical Reactivity of Aldimines from 2,2-Dimethyl-3-oxo-3-phenylpropanal
Armesto, Diego,Ramos, Ana,Perez-Ossorio, Rafael,Horspool, William M.
, p. 91 - 94 (2007/10/02)
The syntheses of some thermally labile aldimines of 2,2-dimethyl-3-oxo-3-phenylpropanal are described.The aldimines (7a-c) are photochemically reactive and undergo fission mainly into isopropyl phenyl ketone.Several other minor products are also formed.On
The Dehydration of Ureas by Two-Phase Dichlorocarbene Reaction, a Synthetic Access to Substituted Cyanamides
Schroth, W.,Kluge, H.,Frach, R.,Hodek, W.,Schaedler, H. D.
, p. 787 - 802 (2007/10/02)
A wide variety of N,N-disubstituted ureas are dehydrated in the CHCl3/NaOH catalytic two-phase system under mild conditions.The sequence of urea-transamidation and dehydration thus offers a profitable approach to aprotic cyanamides.Among various tested PT-catalysts tertiary amines prove to be the most efficient and favourable ones.Tertiary amines may also be used advantageously in the transformation of carboxylic amides and thioamides to the corresponding nitriles.The application of the same technique is less suitable in the case of N-mono-substituted ureas, N,N'-disubstituted ureas as well as N(dialkylaminomethylidene)ureas, because consequent reactions of the primarily formed cyanamides predominate.Problems concerning the dehydration mechanism are elucidated in terms of HMO-perturbation theory.
