5981-39-5

Upstream product

• 83-40-9 3-methylsalicylic acid 
• 1975-52-6 5-nitro-o-toluic acid 

Downstream Products

• 108724-98-7 2,5-diacetoxy-3-methyl-benzoic acid 
• 100940-11-2 2,5-dimethoxy-3-methylbenzoic acid 
• 38102-58-8 2-hydroxy-5-methoxy-3-methyl-benzoic acid methyl ester 
• 197583-33-8 2,5-diprenyloxybenzoic acid 
• 1346151-00-5 methyl 5-methoxy-2-(2-methoxy-2-oxoethoxy)-3-methylbenzoate 
• 1346151-01-6 2-(carboxymethoxy)-5-methoxy-3-methylbenzoic acid 
• 62416-27-7 5-methyl-3,6-dioxo-cyclohexa-1,4-dienecarboxylic acid methyl ester 
• 88208-68-8 methyl 2,5-dimethoxy-3-methylbenzoate 
• 160774-33-4 methyl 2,5-dihydroxy-3-methylbenzoate 

Relevant academic research and scientific papers

2,5- OR 2,6-DISUBSTITUTED HYDROQUINONE DERIVATIVES WITH AT LEAST ONE CARBOXY, SULFO OR AMIDO GROUP USEFUL AS MEDICAMENTS

The invention provides hydroquinone derivatives of formula (I), processes of preparation, as well as pharmaceutical compositions and methods of treating and/or preventing e.g. autoimmune, immunological, rheumatology, vascular, ophthalmologic, fibrotic, me

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

Approaches to the Synthesis of 4-Hydroxypiloquinone

The synthesis of 4-acetoxy-1,8-dihydroxy-2-methyl-3-(4-methylpentanoyl)phenanthrene-9,10-quinone (30) and 1,4,8-trimethoxy-2-methyl-3-(4-methylpentanoyl)phenanthrene-9,10-quinone (33), derivatives of the mould metabolite 4-hydroxypiloquinone (2) are desribed.Photocyclization of methyl 2,2',5,6'-tetramethoxy-3-methylstilbene-4-carboxylate (21) provided methyl 1,4,8-trimethoxy-2-methylphenanthrene-3-carboxylate (22), suitable for further elaboration into the natural derivatives.