59819-52-2

Usage

InChI:InChI=1/C8H6Cl5O3P/c9-6-3-1-2-4-7(6)16-17(13,14)15-5-8(10,11)12/h1-4H,5H2

Downstream Products

• 71260-69-0 Hexadecanoic acid 2-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-1-hexadecanoyloxymethyl-ethyl ester 
• 74212-26-3 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,2,2-trichloro-ethyl ester 
• 78120-26-0 allyl-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-α-D-glucopyranosyl 6-O-<2,2,2-trichloroethyl 2-chlorophenyl phosphate> 
• 77057-93-3 5'-O-(tert-butyldimethylsilyl)-3'-O-methyl-6-N-p-anisoyladenosine 2'-O-(2,2,2-trichloroethyl 2-chlorophenylphosphate) 
• 76991-45-2 5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate) 
• 74212-28-5 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(3,4-dimethyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,2,2-trichloro-ethyl ester 
• 74212-27-4 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(3,4-dichloro-benzoylamino)-6-oxo-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,2,2-trichloro-ethyl ester 
• 104826-47-3 1,2,3,4-tetra-O-benzyl-D-ribitol 5-(2,2,2-trichloroethyl 2-chlorophenyl phosphate) 
• 79851-09-5 (4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 
• 63358-76-9 N⁶-(4-methoxy-benzoyl)-O^2'-(4-methoxy-tetrahydro-pyran-4-yl)-O^5'-(4-oxo-pentanoyl)-[3']adenylic acid 2-chloro-phenyl ester 2,2,2-trichloroethyl ester 
• 79838-11-2 (4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 
• 74212-29-6 Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,2,2-trichloro-ethyl ester 
• 78120-28-2 trans-1-propenyl-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-α-D-glucopyranosyl 6-O-<2,2,2-trichloroethyl 2-chlorophenyl phosphate> 
• 76991-58-7 C₅₆H₆₂Cl₂N₁₀O₁₇P₂Si 

Relevant academic research and scientific papers

PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME

A penem derivative represented by the following formula (I): wherein R1represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted alkenylthio group, a substituted or unsubstituted aralkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted heterocyclic thio group, a substituted or unsubstituted acylthio group, a mercapto group or a hydrogen atom, and R2represents a hydrogen atom or a carboxyl-protecting group; or a pharmacologically acceptable salt thereof. The compound (I) exhibits strong antibacterial activities, and especially, shows strong activities against MRSA. It is therefore useful not only as a general antibacterial agent but also as an antibacterial agent for MRSA against which no general antibacterial agents are recognized to be effective.

Enzymatic process for 3-substituted cephalosporins

6β-(3-Carboxyphenylacetylamino)-2α-substituted--2β-methylpenam-3-carboxylic acids and 6β-adipoylamino--2α-substituted-2β-methylpenam-3-carboxylic acids, wherein the α-substituent is C1-C3 alkyl, C1-C3 alkoxy, vinyl or allenyl, are converted by the enzyme deacetoxy-cephalosporin C synthetase to the 7β-(3-carboxyphenyl-acetylamino)-3-substituted-3-cephem-4-carboxylic acid and the 7β-adipoylamino-3-substituted-3-cephem-4-car-boxylic acid.

Process for preparing cephalosporin esters in the presence of liquid sulfur dioxide

A process for preparing a cephalosporin ester which comprises subjecting an organic halide or an alcohol to reaction with a cephalosporin acid, a cephalosporin acid halide or a salt thereof in the presence of liquid sulfur dioxide.