59855-01-5

Upstream product

• 109233-69-4 methyl p-(5-heptylpyrimidyl)-benzoate 
• 59854-97-6 5-n-heptyl-2-(4-cyanophenyl)-pyrimidine 
• 57202-66-1 2-heptyl-3-dimethylaminoacrolein 
• 42823-73-4 4-amidinobenzoic acid methyl ester hydrochloride 

Downstream Products

• 123704-55-2 C₃₆H₄₀N₂O₄ 
• 123704-56-3 C₃₂H₂₉N₃O₄ 
• 123704-57-4 2-Chloro-4-[4-(5-heptyl-pyrimidin-2-yl)-benzoyloxy]-benzoic acid 4-cyano-phenyl ester 
• 123704-54-1 5-Cyanophenyl p-benzoate 
• 108768-42-9 4-(5-Heptyl-pyrimidin-2-yl)-benzoic acid 3-chloro-4-cyano-phenyl ester 
• 123704-50-7 4-(5-Heptyl-pyrimidin-2-yl)-benzoic acid 4-pentyl-phenyl ester 
• 123704-52-9 4-(5-Heptyl-pyrimidin-2-yl)-benzoic acid 4-cyano-phenyl ester 
• 123704-51-8 4-(5-Heptyl-pyrimidin-2-yl)-benzoic acid 4-fluoro-phenyl ester 
• 106809-04-5 4-(5-Heptyl-pyrimidin-2-yl)-benzoyl chloride 
• 125150-39-2 (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate 

Relevant academic research and scientific papers

Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands

We recently discovered the isoform selective RARβ2 ligand 4′-octyl-4-biphenylcarboxylic acid (3, AC-55649). Although 3 is highly potent at RARβ2 and displays excellent selectivity, solubility issues make it unsuitable for drug development. Herein we descr

COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS

Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders such as memory deficits and schizophrenia, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, inflammatory disorders such as psoriasis and rheumatoid arthritis, eye disorders and depression.

SYNTHESIS AND LIQUID-CRYSTAL PROPERTIES OF ARYL ESTERS OF p-(5-ALKYL-2-PYRIMIDINYL)BENZOIC ACIDS

Aryl esters of p-(5-alkyl-2-pyrimidinyl)benzoic and p-(5-alkyl-2-pyrimidinyl)-benzoyloxybenzoic acids, which displayed nematic properties with broad ranges of the existence of a meso phase, particularly in the case of the diesters (up to 140-170 deg C), were obtained.It is shown that the presence of a 2-phenyl group in the pyrimidine ring favors the development of a liquid-crystal state as compared with 5-phenylpyrimidines.