59860-58-1Relevant academic research and scientific papers
Aliphatic alcohols, their preparation and use of same as perfuming ingredients
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, (2008/06/13)
Novel cycloaliphatic alcohols of formula STR1 wherein each of symbols R1 and R2 designates a methyl radical or wherein R1 designates an ethyl radical and R2 stands for a methyl radical or a hydrogen atom, posses
208. Diastereoselektivitaet der Geruchswahrnehmung von Alkoholen der Iononreihe
Schulte-Elte, Karl H.,Giersch, Wolfgang,Winter, Beat,Pamingle, Herve,Ohloff, Guenther
, p. 1961 - 1985 (2007/10/02)
The characteristic odor of the diastereoisomers 1 and 2 of 1-(2,2,6-trimethylcyclohexyl)-3-hexanol is configuration dependent, the trans-alcohol 1 being identified as the sensorily active component.Structure modifications of model 1/2, for example substitution on C(2), C(13), and C(14) (ionon numbering) by CH3 groups, introduction of double bonds in the 3- or 4-position, and isosteric substitution of C(7) by an O-atom, leads to analogues revealing an unequivocal relation between stereochemistry and odor.The specific odor of alcohol 1 is generally released when all substituents are in an equatorial position; the resulting analogy with the molecular size and shape of odoriferous steroids suggests that the release of the particular scent can be correlated with a steroid-resembling receptor event.
