59865-16-6 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 59865-16-6 differently. You can refer to the following data:
1. Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying cyclosporin A. The pharmacology of isocyclosporin A has received little attention.
2. Cyclosporin A (C988900) impurity.
Check Digit Verification of cas no
The CAS Registry Mumber 59865-16-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,8,6 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 59865-16:
(7*5)+(6*9)+(5*8)+(4*6)+(3*5)+(2*1)+(1*6)=176
176 % 10 = 6
So 59865-16-6 is a valid CAS Registry Number.
InChI:InChI=1/C62H111N11O12/c1-25-27-28-40(15)52-50(63-18)56(78)66-43(26-2)58(80)68(19)33-48(74)69(20)44(29-34(3)4)55(77)67-49(38(11)12)61(83)70(21)45(30-35(5)6)54(76)64-41(16)53(75)65-42(17)57(79)71(22)46(31-36(7)8)59(81)72(23)47(32-37(9)10)60(82)73(24)51(39(13)14)62(84)85-52/h25,27,34-47,49-52,63H,26,28-33H2,1-24H3,(H,64,76)(H,65,75)(H,66,78)(H,67,77)/b27-25-
59865-16-6Relevant articles and documents
1H NMR analysis of isocyclosporin A prepared in organic solvent and in aqueous solution
Arnoldi, Lolita,Manzocchi, Ada,Magni, Fulvio,Del Puppo, Marina,Galli Kienle, Marzia
, p. 110 - 116 (1997)
Isocyclosporins are isomers of cyclosporins deriving from an N,O-acyl transfer occurring under acidic conditions. For the identification by 1H NMR of isocyclosporins prepared in organic solvents the signal at 2.3 ppm assigned to three hydrogens of the NHCH3 group is considered. Results reported here show that the 1H NMR spectrum of isocyclosporin A prepared in aqueous acidic conditions lacks of the above signal and profoundly differs from that of isocyclosporin A prepared in organic solvents, despite the identity of the primary structures determined on the basis of mass spectrometric analysis.
Isolation and structure determination of the new cyclosporins E, F, G, H and I
Traber,Loosli,Hofmann,et al.
, p. 1655 - 1677 (1982)
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