59870-43-8

Basic information

• Product Name: 2-CHLOROQUINAZOLIN-4-AMINE
• Synonyms: IFLAB-BB F2108-0111;2-CHLOROQUINAZOLIN-4-AMINE;Nsc75185;2-Chloroquinazolin-4-ylamine;2-chloro-4-Quinazolinamine;2-Chloro-4-aminoquinazoline;4-Quinazolinamine,2-chloro-;4-Amino-2-chloroquinazoline
• CAS NO: 59870-43-8
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 179.61
• Mol File: 59870-43-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 313.6 °C at 760 mmHg
• Flash Point: 143.5 °C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 0.00049mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-CHLOROQUINAZOLIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROQUINAZOLIN-4-AMINE(59870-43-8)
• EPA Substance Registry System: 2-CHLOROQUINAZOLIN-4-AMINE(59870-43-8)

Safety Data

• Hazardous Substances Data: 59870-43-8(Hazardous Substances Data)

Usage

General Description

2-Chloroquinazolin-4-amine is a chemical compound with the molecular formula C8H6ClN3. It is a derivative of quinazoline, a bicyclic compound that is used in various pharmaceutical applications. 2-CHLOROQUINAZOLIN-4-AMINE is of interest due to its potential use as a building block in organic synthesis and drug discovery. It has been studied for its potential biological and pharmacological activities, and its derivatives have been investigated for their potential as antitumor agents and for their activity as inhibitors of certain enzymes. 2-Chloroquinazolin-4-amine is an important intermediate in the development of various pharmaceuticals and organic compounds.

InChI:InChI=1/C8H6ClN3/c9-8-11-6-4-2-1-3-5(6)7(10)12-8/h1-4H,(H2,10,11,12)

Upstream product

• 607-68-1 2,4-dichloroquinazoline 
• 118-92-3 anthranilic acid 
• 86-96-4 quinazoline-2,4-diol 
• 1336-21-6 ammonium hydroxide 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 67-56-1 methanol 
• 77767-98-7 2-chloro-4-methoxyquinazoline 
• 7664-41-7 ammonia 

Downstream Products

• 1022-44-2 4-amino-2-phenyl-quinazoline 
• 139308-45-5 N²-phenylquinazoline-2,4-diamine 
• 455266-09-8 N₂-[1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-quinazoline-2,4-diamine 
• 749866-16-8 4-amino-2-[trans-(4-aminomethylcyclohexyl)methyamino]quinazoline 
• 253192-03-9 4-[1-(4-Aminoquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 

Relevant articles and documents

-

-

Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity in vitro

The synthesis, cytotoxic activities and selectivities of 35 derivatives related to quinazoline and pyrido[2,3-d]pyrimidine are described. The synthesized compounds were screened in vitro against four tumoral cell lines - leukemia (CCRF-CEM), colon (HT-29), lung (HTB-54) and breast (MCF-7) - and two cell lines derived from non-malignant cell lines, one mammary (184B5) and one from bronchial epithelium (BEAS-2B). MCF-7 and HTB-54 were the most sensitive cell lines with GI50 values below 10 μM for eleven and ten compounds, respectively. Two compounds (2o and 3a) were identified that evoked a marked cytotoxic effect in all cell lines tested and one compound, 7h, was potent and selective against MCF-7. A preliminary study into the mechanism of the potent derivatives 2o, 3a and 7h indicated that the cytotoxic activities of these compounds might be mediated by inducing cell death without affecting cell cycle phases.

USE OF COMPOUNDS FOR PREPARING ANTI-TUBERCULOSIS AGENTS

Compounds of a compound of compound of general formula (I) wherein X1, X2, A, R1R2, R3 and R4 are as defined herein; are useful as anti-mycobacterial agents, especially agents for the treatment of tuberculosis.