59875-43-3

Basic information

• Product Name: Benzeneacetaldehyde, a-(diphenylphosphinyl)-
• CAS NO: 59875-43-3
• Molecular Formula: C20H17O2P
• Molecular Weight: 320.328
• Mol File: 59875-43-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzeneacetaldehyde, a-(diphenylphosphinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetaldehyde, a-(diphenylphosphinyl)-(59875-43-3)
• EPA Substance Registry System: Benzeneacetaldehyde, a-(diphenylphosphinyl)-(59875-43-3)

Safety Data

• Hazardous Substances Data: 59875-43-3(Hazardous Substances Data)

Upstream product

• 4559-70-0 Diphenylphosphine oxide 
• 102-96-5 (2-nitroethenyl)benzene 
• 49749-89-5 (2-nitro-1-phenylethyl)diphenylphosphine oxide 

Downstream Products

• 89841-24-7 (2-hydroxy-1-phenylethyl)diphenylphosphine oxide 

Relevant articles and documents

Synthesis and Horner-Wittig Chemistry of (Fluoromethyl)diphenylphosphane Oxide

(Fluoromethyl)diphenylphosphane oxide (1) was obtained by heating (diphenylphosphinoyl)methyl p-toluenesulfinate (2) with potassium fluoride. Compound 1 is a stable, crystalline solid, suitable for application in the Horner-Wittig reaction. The compound described in the literature under this name was found to be benzylphenylphosphinic fluoride (5). The anion of phosphane oxide 1 readily reacted with a wide range of carbonyl to yield diastereomeric mixtures of α-fluoro-β-(hydroxyalkyl)phosphane oxides (7), which in most cases could be separated. The ease of phosphinate elimination to yield (E)- and (Z)-1-fluoroalkenes 8 stereoselectively was found to be strongly dependent upon conformation and substituent patern. The route presented here avoids the use of hazardous fluorohalomethanes, which were employed in several earlier Wittig-related approaches to vinyl fluorides.