59877-74-6Relevant academic research and scientific papers
STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF
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Paragraph 0284-0286, (2020/12/22)
The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound as shown in formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.
6β,19-Bridged androstenedione analogs as aromatase inhibitors
Komatsu, Sachiko,Yaguchi, Ayaka,Yamashita, Kouwa,Nagaoka, Masao,Numazawa, Mitsuteru
experimental part, p. 884 - 889 (2009/12/01)
Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New 6β,19-bridged steroid analogs of androstenedione, 6β,19-epithio- and 6β,19-methano compounds 11 and 17, were synthesized starting from 19-hydroxyandros
THE SYNTHESIS OF NOVEL BRIDGED A RING STEROIDS
Lan-Hargest, Hsuan-Yin,Elliott, John D.,Eggleston, Drake S.,Holt, Dennis A.,Levy, Mark A.,Metcalf, Brian W.
, p. 6117 - 6120 (2007/10/02)
The novel bridged A ring steroid 1 was synthesized as a potential inhibitor of steroid 5α-reductase.The structure of the key synthetic intermediate, pentacyclic enedione 2 was confirmed by x-ray analysis.
