59878-63-6

Basic information

• Product Name: N-DESMETHYL ZOPICLONE
• Synonyms: N-DESMETHYL ZOPICLONE;N-Desmethyl Zopiclone Hydrochloride;Piperazine -1-carboxylic Acid 6-(5-Chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5yl Ester Hydrochloride;6-(5-CHLOROPYRIDIN-2-YL)-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRAZIN-5-YL PIPERAZINE-1-CARBOXYLATE;Desmethylzopiclone;1-Piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester;N-Desmethyl Zopiclone HCl;6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxyl
• CAS NO: 59878-63-6
• Molecular Formula: C16H16Cl2N6O3
• Molecular Weight: 411.24
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;GABA/Glycine receptor;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard
• Mol File: 59878-63-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 226-2280C
• Boiling Point: 599°C at 760 mmHg
• Flash Point: 316.1°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 2.61E-14mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 8.26±0.10(Predicted)
• CAS DataBase Reference: N-DESMETHYL ZOPICLONE(CAS DataBase Reference)
• NIST Chemistry Reference: N-DESMETHYL ZOPICLONE(59878-63-6)
• EPA Substance Registry System: N-DESMETHYL ZOPICLONE(59878-63-6)

Safety Data

• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 59878-63-6(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

N-Desmethyl Zopiclone is a metabolite of Zopiclone (Z700500), N-Desmethyl Zopiclone is an intermediate in the synthesis of N-Desmethyl Zopiclone Hydrochloride (D296770).

InChI:InChI=1/C16H15ClN6O3/c17-10-1-2-11(21-9-10)23-14(24)12-13(20-4-3-19-12)15(23)26-16(25)22-7-5-18-6-8-22/h1-4,9,15,18H,5-8H2

Upstream product

• 43200-80-2 zopiclon 

Relevant articles and documents

Electrochemical oxidation of zopiclone

Electrochemical behaviour of zopiclone was investigated on glassy carbon electrode in static and rotation disc arrangement. Strong influence of kinetics and adsorption phenomena on the electrode processes was proved by voltammetric techniques. Controlled potential electrolysis in off-line and on-line combination with tandem mass spectrometry was employed for investigation of the products of electrochemical oxidation. N-Desmethyl zopiclone was identified and three other oxidation products formed by an introduction of one or two oxygen atom(s) to the molecule of zopiclone (including zopiclone N-oxide) were characterized. Based on mass spectrometric investigation of those products, piperazine moiety was proved as a target of electrochemical oxidation of zopiclone. Since N-desmethyl zopiclone and zopiclone N-oxide have been reported as products of enzymatic metabolism of the drug, the combination of electrochemistry with mass spectrometry may be considered as a reliable tool for simulation of some metabolic transformations. Graphical abstract: [Figure not available: see fulltext.]