59880-97-6 Usage
Description
TYRAMINE HYDROCHLORIDE is a chemical compound derived from the amino acid tyrosine, which is commonly found in various food products and plays a significant role in the synthesis of certain hormones and neurotransmitters. It is known for its ability to induce leucocyte chemotaxis and activate macrophages, making it a valuable compound in the field of medical and biological research.
Uses
Used in Medical and Biological Research:
TYRAMINE HYDROCHLORIDE is used as a chemotactin peptide for inducing leucocyte chemotaxis and activating macrophages. This application is particularly relevant in the study of polymorphonuclear leukocytes (PMN) and neutrophils, as it helps researchers understand the signaling pathways and immune responses involved in these processes.
Used in Chemotaxis Assays:
In the field of cellular biology, TYRAMINE HYDROCHLORIDE is used as a key component in chemotaxis assays, such as the Zigmond chamber chemotaxis assay performed on neutrophils. These assays are crucial for determining the involvement of specific signaling molecules, like MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathways of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.
Used in Pharmaceutical Industry:
TYRAMINE HYDROCHLORIDE is also utilized in the pharmaceutical industry for the development of drugs targeting various medical conditions. Its role in inducing leucocyte chemotaxis and activating macrophages makes it a potential candidate for the treatment of immune-related disorders and inflammatory diseases.
Biochem/physiol Actions
Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Check Digit Verification of cas no
The CAS Registry Mumber 59880-97-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,8,8 and 0 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59880-97:
(7*5)+(6*9)+(5*8)+(4*8)+(3*0)+(2*9)+(1*7)=186
186 % 10 = 6
So 59880-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
59880-97-6Relevant articles and documents
SYNTHETIC INNATE IMMUNE RECEPTOR LIGANDS AND USES THEREOF
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Paragraph 0054; 0091, (2020/06/10)
An adjuvant formulation includes a monophosphoryl Lipid A (MPLA) analogue, a Pam3CSK4 analogue, or a muramyldipeptide (MDP) analogue, or combinations thereof. The adjuvant may be formulated in soluble form or in a nanoparticle, such as polylactic glycolic acid nanoparticles. A vaccine formulation comprises the adjuvant formulation and an immunogen. Methods of vaccinating an animal include delivering the vaccine formulation to the animal.
Amino acid pyridoxyl esters in peptide synthesis
Sklyarov,Sbitneva,Kopina,Sidorovich
, p. 245 - 256 (2007/10/03)
Pyridoxyl residue was suggested to be used as a multifunctional protective and modifying group in peptide synthesis. The modification was carried out by introducing the pyridoxyl residue in free or partially protected peptides or by the addition of amino
N-BENZHYDRYL-GLYCOLAMIDE ESTERS (OBg ESTERS) AS CARBOXYL PROTECTING GROUPS IN PEPTIDE SYNTHESIS
Amblard, Muriel,Rodriguez, Marc,Martinez, Jean
, p. 5101 - 5108 (2007/10/02)
N-benzhydryl-glycolamide esters (OBg esters) of various N-protected amino acids have been synthesized.In order to demonstrate their usefulness in peptide chemistry, the syntheses of For-Met-Leu-Phe-OH (chemiotactic peptide) and Pro-Leu-Gly-NH2 (MIF) have been carried out.OBg esters are compatible with commonly used protecting groups and are cleanly and selectively removed in mild alkaline conditions without any side reaction, except for β-benzyl aspartyl containing sequences.