59880-97-6

Basic information

• Product Name: TYRAMINE HYDROCHLORIDE
• Synonyms: P-(2-AMINOETHYL)PHENOL HYDROCHLORIDE;TIMTEC-BB SBB003808;TYROSAMINE HCL;TYROSAMINE HYDROCHLORIDE;TYRAMINE HCL;TYRAMINE MONOHYDROCHLORIDE;4-HYDROXYPHENYLETHYLAMINE HCL;2-(4-HYDROXYPHENYL)ETHYLAMINE HCL
• CAS NO: 59880-97-6
• Molecular Formula: C₂₁H₃₁N₃O₅S
• Molecular Weight: 437.56
• EINECS: 200-462-5
• Mol File: 59880-97-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 271-274 °C(lit.)
• Boiling Point: 269 °C
• Flash Point: 427.7°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 7.43E-26mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• Solubility: DMF: 50 mg/mL, clear, colorless
• PKA: 3.50±0.10(Predicted)
• BRN: 2315783
• CAS DataBase Reference: TYRAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TYRAMINE HYDROCHLORIDE(59880-97-6)
• EPA Substance Registry System: TYRAMINE HYDROCHLORIDE(59880-97-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-22
• WGK Germany: 3
• RTECS: SJ6050000
• F: 3-10
• Hazardous Substances Data: 59880-97-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 59880-97-6 differently. You can refer to the following data:
1. Induces leucocyte chemotaxis, and activates macrophages
2. N-Formyl-Met-Leu-Phe has been used for:creating gradients in Zigmond chamber chemotaxis assay performed on neutrophilsuse in neutrophil chemotaix assay anddetermination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

Definition

ChEBI: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.

General Description

N-Formyl-Met-Leu-Phe is a chemotactin peptide, which functions on polymorphonuclear leukocytes (PMN), neutrophils etc.

Biochem/physiol Actions

Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.

InChI:InChI=1/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

Upstream product

• 70637-32-0 formyl-Met-Leu-Phe-OCH₂C₆H₅ 
• 98229-02-8 For-L-Met-L-Leu-L-Phe-CAM 
• 119706-26-2 For-Met-Leu-Phe-OBg 
• 285131-19-3 2-[2-(2-formylamino-4-methylsulfanyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-ylmethyl ester 
• 64-18-6 formic acid 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 259106-70-2 N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester 
• 3392-09-4 Boc-Leu-ONSu 
• 1738-77-8 L-leucine benzyl ester p-toluenesulfonate 
• 77543-00-1 N-formylmethionylleucylphenylalanine methyl ester 
• 70637-29-5 Boc-Met-Leu-Phe-OCH₂C₆H₅ 
• 70637-30-8 H-Met-Leu-Phe-O-CH₂C₆H₅ 
• 70637-27-3 Leu-Phe-OBzl 

Downstream Products

• 1204605-14-0 for-Met-Leu-Phe-Lys(Phe-Leu-Met-for)-εLys(OMe)-Phe-Leu-Met-for 
• 1204605-12-8 for-Met-Leu-Phe-Lys[γ-Asp(OMe)-Phe-Leu-Met-for]-OMe 
• 1204605-15-1 for-Met-Leu-Phe-Lys(Phe-Leu-Met-for)-Lys(Phe-Leu-Met-for)-OMe 
• 1204605-13-9 for-Met-Leu-Phe-Lys(Phe-Leu-Met-for)-OMe 

Relevant articles and documents

SYNTHETIC INNATE IMMUNE RECEPTOR LIGANDS AND USES THEREOF

An adjuvant formulation includes a monophosphoryl Lipid A (MPLA) analogue, a Pam3CSK4 analogue, or a muramyldipeptide (MDP) analogue, or combinations thereof. The adjuvant may be formulated in soluble form or in a nanoparticle, such as polylactic glycolic acid nanoparticles. A vaccine formulation comprises the adjuvant formulation and an immunogen. Methods of vaccinating an animal include delivering the vaccine formulation to the animal.

Amino acid pyridoxyl esters in peptide synthesis

Pyridoxyl residue was suggested to be used as a multifunctional protective and modifying group in peptide synthesis. The modification was carried out by introducing the pyridoxyl residue in free or partially protected peptides or by the addition of amino

N-BENZHYDRYL-GLYCOLAMIDE ESTERS (OBg ESTERS) AS CARBOXYL PROTECTING GROUPS IN PEPTIDE SYNTHESIS

N-benzhydryl-glycolamide esters (OBg esters) of various N-protected amino acids have been synthesized.In order to demonstrate their usefulness in peptide chemistry, the syntheses of For-Met-Leu-Phe-OH (chemiotactic peptide) and Pro-Leu-Gly-NH2 (MIF) have been carried out.OBg esters are compatible with commonly used protecting groups and are cleanly and selectively removed in mild alkaline conditions without any side reaction, except for β-benzyl aspartyl containing sequences.