59883-21-5Relevant academic research and scientific papers
Regioselective lactonization of unsymmetrical 1,4-diols: An efficient access to lactone lignans
Ito, Masato,Shiibashi, Akira,Ikariya, Takao
supporting information; experimental part, p. 2134 - 2136 (2011/04/21)
A Cp*Ru-based bifunctional catalyst system (Cp* = η5-C5(CH3)5) with a suitably-designed PN ligand (PN = chelating tertiary phosphine-protic amine ligand) has been developed for a regioselective lactonization of
Regio-Controlled Ene-Yne Photochemical Cycloaddition Using Silicon As A Tether
Bradford, Cara L.,Fleming, Steven A.,Ward, Susan C.
, p. 4189 - 4192 (2007/10/02)
Substituted cyclobutenes were synthesized by irradiation of silicon tethered ene-ynes.Irradiation of a silicon tethered bisphenylalkyne resulted in cycloaddition and rearrangement to a substituted naphthalene.A diradical intermediate which resembles known DNA cleaving molecules is proposed. - Key Words: 2+2 photocycloaddition, alkoxysilane photochemistry, cyclobutene synthesis
Analgesic basic naphthalene derivatives
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, (2008/06/13)
Compounds of the general formula: STR1 wherein the groups CHR1 NR2 R3 and CHR4 NR5 R6 may be the same or different and where the group CHR4 NR5 R6 is in either the 1 or the 3 position and R1 and R4 independently represent a hydrogen atom or an aryl group; R2, r3, r5 and R6 which may be the same or different are each a hydrogen atom or an alkyl group or an aryl group both of which may in turn be substituted by one or more hydroxy, alkoxy, acyloxy, dialkylamino or aryl groups or the groups --NR2 R3 and/or NR5 R6 represent a heterocyclic ring containing one or more hetero atoms and which ring may optionally be substituted by an alkyl, aryl or aralkyl group and in which either aromatic ring of the naphthalene nucleus may be further substituted; with the proviso that when R1, R4, R2 and R5 are hydrogen, then R3 and R6 cannot both be benzyl, when the second substituent is in the 1 position; and when R1 and R4 are hydrogen, then R2, R3, R5 and R6 cannot all be methyl when the second substituent is in the 1 position; and when R1 and R4 are hydrogen, then R2 and R3 and R5 and R6 together with the nitrogen atom cannot both be piperidino when the second substituent is in the 3 position and the naphthalene nucleus is further substituted by hydroxy in the 1 and 4 positions; and pharmaceutically acceptable salts of such compounds; and hydrates of such compounds and such salts. The compounds have activity on the central nervous system in particular as analgesics.
