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2,5-bis(aziridin-1-yl)-3,6-bis[4-(2-hydroxyethyl)piperazin-1-yl]cyclohexa-2,5-diene-1,4-dione, commonly known as busulfan, is a bifunctional alkylating agent with significant applications in the field of oncology. It is characterized by its ability to bind to DNA, thereby disrupting the replication and transcription processes, which results in the death of cancer cells. Due to its potent and toxic nature, busulfan requires careful administration and monitoring to manage its serious side effects.

59886-40-7

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59886-40-7 Usage

Uses

Used in Oncology:
Busulfan is used as a chemotherapeutic agent for the treatment of certain types of cancer, specifically chronic myelogenous leukemia. It is effective due to its ability to alkylate and cross-link DNA strands, which inhibits the growth and proliferation of cancerous cells.
Used in Bone Marrow Suppression Management:
Although a side effect of busulfan treatment, its骨髓suppression property is utilized in conditions where a reduction in bone marrow activity is therapeutically beneficial, such as in the preparation for bone marrow transplantation.
Used in Drug Formulation:
Busulfan is formulated into various pharmaceutical products for intravenous or oral administration. Its formulation requires careful consideration to ensure the safe and effective delivery of the drug to patients.
Used in Healthcare Supervision:
Due to the serious side effects associated with busulfan, it is used under the strict supervision of healthcare professionals. This includes the monitoring of blood counts and liver function to mitigate the risks associated with its use.
Used in Research and Development:
Busulfan's unique mechanism of action makes it a subject of interest in research for the development of new cancer treatments and to understand the molecular mechanisms of DNA alkylation and its implications in cancer therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 59886-40-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,8,8 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 59886-40:
(7*5)+(6*9)+(5*8)+(4*8)+(3*6)+(2*4)+(1*0)=187
187 % 10 = 7
So 59886-40-7 is a valid CAS Registry Number.

59886-40-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-bis(aziridin-1-yl)-3,6-bis[4-(2-hydroxyethyl)piperazin-1-yl]cyclohexa-2,5-diene-1,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59886-40-7 SDS

59886-40-7Upstream product

59886-40-7Downstream Products

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