59897-70-0Relevant academic research and scientific papers
Carbon disulfide promoted reactions of 2-chloro-4,5-dihydro-imidazole with some n-nucleophiles
Saczewski,Saczewski,Gdaniec
, p. 1203 - 1206 (2001)
The reactions of 2-chloro-4,5-dihydroimidazole 1 with o-substituted anilines and azoles promoted by carbon disulfide have been carried out. Ab initio MO calculations were used to elucidate the mechanism of the reaction of 1 with N-nucleophilic reagents. A facile synthesis of 2-(4,5-dihydroimidazol-2-yl)-1H-indazole 3e bearing structural resemblances to 2-BFI, a potent and selective agonist of imidazoline I2 receptors, is also described. Structure of 3e was confirmed by NMR spectroscopy and X-ray analysis.
