59902-87-3Relevant academic research and scientific papers
Visible-Light-Promoted Radical Cyclization of N -Arylvinylsulfonamides: Synthesis of CF 3/CHF 2/CH 2CF 3-Containing 1,3-Dihydrobenzo[ c ]isothiazole 2,2-Dioxide Derivatives
Vytla, Devaiah,Kaliyaperumal, Kumargurubaran,Velayuthaperumal, Rajeswari,Shaw, Parinita,Gautam, Raj,Mathur, Arvind,Roy, Amrita
supporting information, p. 667 - 682 (2021/11/13)
A photocatalyzed and highly efficient trifluoromethylation of N-arylvinylsulfonamides using commercially available CF3SO2Cl as the trifluoromethyl radical source under blue LEDs is reported. The reaction proceeds through radical cyclization under mild con
Selective lysine modification of native peptides: Via aza-Michael addition
Chen, Hongli,Huang, Rong,Li, Zhihong,Zhu, Wei,Chen, Jiakang,Zhan, Yuexiong,Jiang, Biao
supporting information, p. 7339 - 7345 (2017/09/25)
A series of vinylsulfonamides were synthesized and screened for site-selective modification of the ?-amino group of lysine-bearing free α-amine residues. N-Methyl-N-phenylethenesulfonamide has emerged as an applicable reagent and has been developed for efficient and highly selective modification of the lysine residue of native peptides in the presence of a free N-terminus via aza-Michael addition. We demonstrated that functional N-phenylvinylsulfonamide derivatives with a fluorescent moiety or drug could also be conjugated to the lysine residue of octreotide and insulin with high specificity, without modifying the N-terminus. Our method provides a promising strategy for site-selective lysine functionalization in native peptides with a free N-terminus.
