599161-61-2Relevant academic research and scientific papers
Palladium-catalyzed amidation of N-tosylhydrazones with isocyanides
Zhou, Fengtao,Ding, Ke,Cai, Qian
, p. 12268 - 12271 (2011)
Aminocarbonylation of N-tosylhydrazones: The direct formation of ketenimines from carbenes and isocyanides is limited to the reaction of Fischer carbene complexes or some specially stabilized carbenes with isocyanides. A Pd-catalyzed amidation of N-tosylhydrazones with isocyanides via a ketenimine intermediate in the presence of water is described. The method offers a general way to synthesize amides from carbonyl compounds through one-carbon extension (see scheme). Copyright
