599178-71-9

Upstream product

• 3218-36-8 4-Phenylbenzaldehyde 
• 599178-66-2 3-(1-1'-biphenyl)-2-acetylamino acrylic acid 
• 1188995-14-3 (Z)-4-([1,10-biphenyl]-4-ylmethylene)-2-methyloxazol-5(4H)-one 
• 63024-22-6 2-acetylamino-2-(4-phenyl benzyl) malonic acid 
• 63024-50-0 2-acetylamino-3-(biphenyl-4-yl)-propanoic acid 
• 1236479-66-5 (L)-2-acetylamino-3-(biphenyl-4-yl)-propanoic acid-(R)-1-phenethylamine salt 

Relevant academic research and scientific papers

Preparation method of chiral alpha-amino acid

The invention discloses a preparation method of chiral alpha-amino acid. Initial raw materials comprising aldehyde and N-acryl substituted glycine undergo Erlenmeyer-Plochl cyclization, hydrolysis or alcoholysis, asymmetric catalytic hydrogenation and acid hydrolysis to obtain the chiral alpha-amino acid compound. The method adopting the above synthesis route has the advantages of mild reaction conditions, simple technological operation, safe and stable production, realization of high yield, good chemical purity and good optical purity of the above obtained product, wide application range, and suitableness for industrial production.

PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID

The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.

PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID

Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid and intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.