59944-65-9

Basic information

• Product Name: 4-METHYL-1,2,3-THIADIAZOLE-5-CARBONYL CHLORIDE
• Synonyms: TIMTEC-BB SBB005466;BUTTPARK 30\06-42;4-METHYL-1,2,3-THIADIAZOLE-5-CARBONYL CHLORIDE;4-METHYL-1,2,3-THIODIAZOLE-5-CARBONYL CHLORIDE;1,2,3-Thiadiazole-5-carbonyl chloride, 4-methyl- (9CI);4-METHYL-1,2,3-THIADIAZOL-5-CARBONYL CHLORIDE;5-(Chlorocarbonyl)-4-methyl-1,2,3-thiadiazole;5-(Chlorocarbonyl)-4-methyl-1,2,3-thiadiazole, 5-(Chloroformyl)-4-methyl-1,2,3-thiadiazole
• CAS NO: 59944-65-9
• Molecular Formula: C₄H₃ClN₂OS
• Molecular Weight: 162.6
• Product Categories: ACIDHALIDE
• Mol File: 59944-65-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 104 °C
• Flash Point: 98.9 °C
• Appearance: /
• Density: 1.504g/cm³
• Vapor Pressure: 0.0391mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 4-METHYL-1,2,3-THIADIAZOLE-5-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-1,2,3-THIADIAZOLE-5-CARBONYL CHLORIDE(59944-65-9)
• EPA Substance Registry System: 4-METHYL-1,2,3-THIADIAZOLE-5-CARBONYL CHLORIDE(59944-65-9)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 59944-65-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Methyl-1,2,3-thiadiazole-5-carbonyl chloride is used as a key intermediate for the synthesis of potential drugs. It facilitates the introduction of the 4-methyl-1,2,3-thiadiazole-5-carbonyl group into a wide range of organic molecules, enhancing their therapeutic properties and applications in medicine.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methyl-1,2,3-thiadiazole-5-carbonyl chloride serves as a valuable building block for the preparation of various agrochemicals. Its incorporation into organic molecules can improve the effectiveness of these chemicals in agricultural applications.
Safety Note:
It is crucial to handle 4-Methyl-1,2,3-thiadiazole-5-carbonyl chloride with care due to its corrosive nature, which may cause severe skin and eye irritation. Proper safety measures should be taken during its use to prevent any adverse effects.

InChI:InChI=1/C4H3ClN2OS/c1-2-3(4(5)8)9-7-6-2/h1H3

Upstream product

• 18212-21-0 4-methyl-[1,2,3]thiadiazole-5-carboxylic acid 

Downstream Products

• 78875-51-1 (4-Chloro-phenyl)-(4-methyl-[1,2,3]thiadiazol-5-yl)-methanone 
• 183306-64-1 N,N'-p-phenylenebis(4-methyl-1,2,3-thiadiazole-5-carboxamide) 
• 1430197-22-0 4-methyl-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 
• 1430197-23-1 N-(5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamide 
• 1430197-24-2 N-(5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamide 
• 1430197-25-3 4-methyl-N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 
• 1430197-26-4 N-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamide 
• 1430197-27-5 4-methyl-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 
• 1430197-28-6 4-methyl-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 
• 1430197-29-7 N-(5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamide 
• 1448807-50-8 N-[4-(3,4-dimethoxyphenyl)-2-thienyl]-4-methylthiadiazole-5-carboxamide 
• 1401619-46-2 C₂₁H₁₆N₄O₃S 

Relevant articles and documents

IMIDE DERIVATIVE AND FUNGICIDE CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT

The present invention provides an imide derivative represented by the following formula (1): wherein R1 is substituted by a substituent such as an isothiazolyl group, Q is substituted by a substituent such as a thiophenyl group, and A is substituted by a substituent such as a pyrazolyl group, and an agricultural and horticultural fungicide offering an excellent fungicidal effect in agricultural and horticultural situations, which is characterized by containing the imide derivative as an active ingredient.

Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers

Aberrant activation of mast cells contributes to the development of numerous diseases including cancer, autoimmune disorders, as well as diabetes and its complications. The influx of extracellular calcium via the highly calcium selective calcium-release activated calcium (CRAC) channel controls mast cell functions. Intracellular calcium homeostasis in mast cells can be maintained via the modulation of the CRAC channel, representing a critical point for therapeutic interventions. We describe the structure-activity relationship study (SAR) of indazole-3-carboxamides as potent CRAC channel blockers and their ability to stabilize mast cells. Our SAR results show that the unique regiochemistry of the amide linker is critical for the inhibition of calcium influx, the release of the pro-inflammatory mediators β-hexosaminidase and tumor necrosis factor α by activated mast cells. Thus, the indazole-3-carboxamide 12d actively inhibits calcium influx and stabilizes mast cells with sub-μM IC50. In contrast, its reverse amide isomer 9c is inactive in the calcium influx assay even at 100?μM concentration. This requirement of the specific 3-carboxamide regiochemistry in indazoles is unprecedented in known CRAC channel blockers. The new structural scaffolds described in this report expand the structural diversity of the CRAC channel blockers and may lead to the discovery of novel immune modulators for the treatment of human diseases.

Substituted benzo - 1, 3 - [...] compound, its preparation and use

The invention relates to a substituted benzo-1, 3-miscellaneous azole compound shown in the general formula I, and further relates to a preparation method of the compound and application to the preparation of antituberculosis drugs. The compound provided by the invention has effect not only on mycobacterium tuberculosis sensitive strains, but also on resistant strains which have drug resistance to isoniazid, rifampicin, and other traditional frontline antituberculosis drugs, and is a novel antimycobacterium tuberculosis compound.

1. 2, 3 - thiadiazole - 5 - a amidine compound synthesis method

The invention discloses a novel method for synthesizing a 1,2,3-thiadiazole-5-formamidine compound. The target compound shown in general formula TDCA is prepared from a compound as shown in general formula M by virtue of a methylation reaction. The target component as shown in the general formula M is prepared from a compound as shown in general formula A and a compound as shown in general formula N by virtue of a condensation reaction, wherein during the methylation reaction, preferably, a catalyst is an organic metallic catalyst consisting of cuprous iodide and a ligand, namely 2,2,6,6-tetramethyl-3,5-heptadione; during the reaction, preferably, dimethylbenzene is taken as a solvent, and the optimum reaction temperature is 100-140 DEG C. The method disclosed by the invention is high in yield and more environment-friendly (as shown in Specification).

guan Huanfa synthetic multi-nitrogen heterocyclic ring sai oxadiazole - 5 - a amidine compounds

The invention discloses an N-trisubstituted-1,2,3-thiadiazoles-5-formamidine target compound of which the general formula is TDCA. The N-trisubstituted-1,2,3-thiadiazoles-5-formamidine target compound is obtained from an M compound through a cyclization reaction. The new synthetizing method is high in yield, catalysts are easy to prepare, the catalysts are low in cost, phosphoric waste water is less, and the multi-nitrogen heterocycle thiadiazoles-5-formamidine compound is environment-friendly. (As shown in the Description).

Three nitrogen heterocycle containing 1, 2, 3 - thiadiazole - 5 - a amidine compounds and synthesis

The invention discloses an N-trisubstituted-1,2,3-thiadiazole-5-formamidine compound with three aromatic rings of general formula TDCA and a synthesis method of N-trisubstituted-1,2,3-thiadiazole-5-formamidine compound. The target compound of general formula TDCA is obtained by reacting a compound of general formula B and a compound of general formula A, wherein references of X and Y in the general formula A are the same as those in the general formula TDCA.

A containing 1, 2, 3 - thiadiazole pyrazole double-amide compound and its synthetic method and application

The invention belongs to the technical field of organic synthesis and discloses a pyrazol bi-amide compound containing 1,2,3-thiadiazole and a synthetic method and application thereof. The compound has a structure of a general formula I shown in the specification. When the compound is prepared, firstly, a 4-amino pyrazole intermediate and a 1,2,3-thiadiazole formyl chloride intermediate are synthesized; secondly, the 4-amino pyrazole intermediate and the 1,2,3-thiadiazole formyl chloride intermediate are condensed according to a conventional condensation reaction condition, and then the compound of the general formula I can be synthesized. The compound has the superior mosquito larva killing activity and certain armyworm killing activity, and part of the compound has the anti-tobacco mosaic virus activity and bactericidal activity. The compound is novel in structure and large in space of modification and improvement, the preparing method is reasonable and practical, the compound can serve as a pesticide activity lead for deep studying, can serve as mosquitocide to be applied and has potential production and application value.

A kind of 1, 2, 3-thiadiazole Carbamoyl urea compound and its preparation and use

The invention provides bi(4-methyl-1,2,3-thiadiazole-5-phenurone) compounds and a preparation method and application thereof and relates to heterocyclic compounds containing 1,2,3-thiadiazole. The heterocyclic compounds have the following structural formula shown as in the specification of the invention. The invention discloses a structural general formula and a synthetic method of the compounds and application of the compounds as pesticides, bactericides, plant virus resisting agents and plant activating agents; a process for preparing the pesticides, the bactericides, the plant virus resistant agents and the plant activating agents by mixing the compounds with agriculturally-acceptable assistants or synergistic agents; and application of combination of the compounds and commercial pesticides, the bactericides, the plant virus resisting agents and the plant activating agents to controlling diseases, insect pests and virus diseases in agriculture, forestry and gardening and a preparation method.

Containing 4-methyl -1, 2, 3-thiadiazole carboxamidine derivatives and process for their preparation and use

The invention provides formamidine derivatives containing 4-methyl-1,2,3-thiadiazole, and preparation methods and uses thereof. The invention relates to formamidine compounds containing 1,2,3-thiadiazole, wherein the compounds have the chemical structural general formula expressed by the formula I. The invention discloses the structural general formula and the synthetic method of the compounds, and use of the compounds as a pesticide, an acaricide, a bactericide and an antiphytovirucide, and a processing technique of preparing the pesticide, the acaricide, the bactericide and the antiphytovirucide by mixing the compounds with agriculturally acceptable auxiliaries or synergists. Besides, the invention also discloses the use of the compounds in preventing and treating agricultural, forestal and horticultural diseases, insect pests, mites and virus diseases in combination with commercial pesticide, acaricide, bactericide, antiphytovirucide and plant activator, and preparation methods.

Substituted 1,3-miscellaneous azole compound, preparation method thereof, pharmaceutical composition containing substituted 1,3-miscellaneous azole compound and purpose thereof

The invention relates to a substituted 1,3-miscellaneous azole compound, a preparation method thereof, a pharmaceutical composition containing the substituted 1,3-miscellaneous azole compound and a purpose thereof. The invention relates to the compound in a formula I, or its pharmaceutically acceptable salt, a stereisomer or a solvate, wherein R1, R2, R3 and X are defined as a specification; and the invention also relates to the preparation method, the pharmaceutical composition containing the substituted 1,3-miscellaneous azole compound and the purpose thereof. The compound of the present invention is the novel antituberculous compound, is effective to mycobacterium tuberculosis-susceptible strains, also possesses activity on strains with tolerance on traditional first-line antituberculous drugs such as isoniazide and rifampicin, and has good selectivity to mycobacterium tuberculosis.