59960-32-6

Basic information

• Product Name: Dihydro Ketoprofen (Mixture of Diastereomers)
• Synonyms: 3-(Hydroxyphenylmethyl)-α-methylbenzeneacetic Acid;Dihydro Ketoprofen (Mixture of Diastereomers);Dihydroketoprofen;3-(Hydroxyphenylmethyl)-a-methylbenzeneacetic Acid;3-(Hydroxyphenylmethyl)-alpha-methylbenzeneacetic acid;Dihydro Ketoprofen\n(Mixture of Diastereomers)
• CAS NO: 59960-32-6
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.3
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 59960-32-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 118-120°C
• Boiling Point: 433.6°C at 760 mmHg
• Flash Point: 230.2°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 2.75E-08mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Dihydro Ketoprofen (Mixture of Diastereomers)(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydro Ketoprofen (Mixture of Diastereomers)(59960-32-6)
• EPA Substance Registry System: Dihydro Ketoprofen (Mixture of Diastereomers)(59960-32-6)

Safety Data

• Hazardous Substances Data: 59960-32-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 59960-32-6 differently. You can refer to the following data:
1. A metabolite of Ketoprofen
2. A metabolite of Ketoprofen.

InChI:InChI=1/C16H16O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11,15,17H,1H3,(H,18,19)

Upstream product

• 84548-82-3 5-benzoylbenzothiophene-3-carboxylic acid 
• 22071-15-4 ketoprofen 
• 84548-75-4 5-benzyl-3-carboxymethylbenzothiophene 
• 82787-77-7 5-bromomethyl-3-carboxymethylbenzothiophene 
• 82787-73-3 methyl 5-methylbenzo-thiophene-3-carboxylate 
• 41892-87-9 5-methyl-benzo[b]thiophene-2,3-dicarboxylic acid 
• 2084-24-4 5-Methylbenzothiophene-3-carboxylic acid 
• 50891-89-9 5-methyl-benzo[b]thiophene-2,3-dione 
• 57872-48-7 ketoprofen methyl ester 
• 138682-99-2 methyl 2-(3-(hydroxy-phenyl-methyl)-phenyl)-propionate 
• 74614-67-8 α-(3-benzoylphenyl)acrylic acid 
• 84548-80-1 5-benzoylbenzothiophene-2,3-dicarboxylic acid 
• 84548-76-5 5-benzoyl-3-carboxymethylbenzothiophene 
• 106-45-6 para-thiocresol 

Downstream Products

• 1218923-35-3 (3-(1-oxo-1-(piperidin-1-yl)propan-2-yl)phenyl)(phenyl)methyl piperidine-1-carboxylate 
• 1218923-34-2 (3-(1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)phenyl)(phenyl)methyl pyrrolidine-1-carboxylate 
• 1218923-27-3 (3-(1-(benzyloxycarbamoyl)ethyl)phenyl)(phenyl)methyl benzyloxycarbamate 
• 1218923-26-2 (3-(1-(ethoxycarbamoyl)ethyl)phenyl)(phenyl)methyl ethoxycarbamate 
• 1218923-25-1 (3-(1-(methoxycarbamoyl)ethyl)phenyl)(phenyl)methyl methoxycarbamate 
• 1218923-24-0 2-(3-(N-benzotriazolcarbonyloxy)(phenyl)(methyl)phenyl) propanoic acid benzotriazolide 
• 1218923-23-9 2-(3-(hydroxy(phenyl)methyl)phenyl)propanoic acid benzotriazolide 

Relevant articles and documents

Dual application of synthesized SnO2 nanoparticles in ion chromatography for sensitive fluorescence determination of ketoprofen in human serum, urine, and canal water samples

The aim of this novel study was to introduce a cheap, simple, sensitive, and green methodology involving the dual application of synthesized porous SnO2 nanoparticles (NPs) for selective conversion of non-fluorescent ketoprofen (KP) into a highly fluorescent species and as a sorbent in a μ-sample preparation method for extraction of KP from the three complex human serum, urine, and canal water samples. The clean separation and sensitive fluorescence determination of KP from these complex samples were carried out by coupling an ion chromatograph with a fluorescence detector (IC-FLD). The sorbent was prepared by a simple chemical precipitation method in water and characterized via various techniques. The porous SnO2 NPs, in addition to their role in the selective conversion of KP into a highly fluorescent species, also act as an effective sorbent for the selective degradation and elimination of polar organics, inorganic matrices, and heavy metals in complex samples. The optimized analytical method exhibited satisfactory linearity for ketoprofen in the concentration range of 0.2-1.5 mg kg-1 with a correlation coefficient (r2) of 0.997. The limit of detection (LOD) and quantification (LOQ) in human serum, urine, and canal water samples were 0.1 μg kg-1, 0.5 μg kg-1, and 0.39 μg kg-1 and 1.3 μg kg-1, 0.3 μg kg-1, and 1.7 μg kg-1, respectively. The method also showed good intra-day and inter-day precisions at the two concentration levels of 0.5 mg kg-1 and 1.3 mg kg-1 in complex samples with the relative standard deviations (RSDs) less than 16.3% (n = 5), and satisfactory recoveries were retrieved in the range of 85.1-101.4% with minimum or no matrix effect.

The novel amidocarbamate derivatives of ketoprofen: Synthesis and biological activity

A series of novel ketoprofen derivatives 4a-j bearing both amide and carbamate functionalities were prepared using the benzotriazole method of carboxylic and hydroxy group activation. Selective reduction of ketoprofen produced hydroxy derivative 2, which

The novel ketoprofen amides - Synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents

The novel amides of ketoprofen and its reduced derivatives (5a-f, 4a-n, 6a-g) with aromatic and cycloalkyl amines or hydroxylamines were prepared and screened for their reducing and cytostatic activity as well as for their ability to inhibit soybean lipox