59968-66-0

Basic information

• Product Name: 2-[(phenylcarbamoyl)amino]benzamide
• Synonyms: 2-[(Phenylcarbamoyl)amino]benzamide; 3-Phenylureidobenzamide; benzamide, 2-[[(phenylamino)carbonyl]amino]-
• CAS NO: 59968-66-0
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.2719
• Mol File: 59968-66-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 364.6°C at 760 mmHg
• Flash Point: 174.3°C
• Density: 1.353g/cm³
• Vapor Pressure: 1.67E-05mmHg at 25°C
• Refractive Index: 1.714
• CAS DataBase Reference: 2-[(phenylcarbamoyl)amino]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(phenylcarbamoyl)amino]benzamide(59968-66-0)
• EPA Substance Registry System: 2-[(phenylcarbamoyl)amino]benzamide(59968-66-0)

Safety Data

• Hazardous Substances Data: 59968-66-0(Hazardous Substances Data)

Usage

Structure

A derivative of benzamide with a phenylcarbamoyl group attached to an amino group on the benzene ring

Pharmaceutical properties

Has potential pharmaceutical properties and is used in medicinal chemistry research

Possible applications

May have potential applications in the development of new therapeutic agents or as a tool in drug discovery research

Importance

Its structure and properties make it a candidate for further investigation as a potential drug candidate or as a molecular probe in biological studies.

Upstream product

• 103-71-9 phenyl isocyanate 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 

Relevant articles and documents

Lanthanide-catalyzed cyclocarbonylation and cyclothiocarbonylation: A facile synthesis of benzannulated 1,3-diheteroatom five- and six-membered heterocycles

La[N(SiMe3)2]3 proves to be an efficient catalyst system for the cyclocarbonylation of 1,2-disubstituted benzenes with isocyanates. In this approach, aryl/alkyl isocyanates react with o-phenylenediamine, o-aminophenol, o-aminothiophenol, catechols and anilines ortho-substituted by CH2NH2 and CONH2 to form, respectively, the corresponding benzimidazolones, benzoxazolones, benzothiazolones, benzodioxolones, 3,4-dihydroquinazolin-2(1H)-one, and quinazolinediones. These results represent the first example of lanthanide-catalyzed carbonylation. This methodology is also applicable for the preparation of various benzannulated 1,3-diheteroatom cyclic thioketones starting from aryl/alkyl isothiocyanates or CS2 in good to excellent yields. Based on the results of experiments performed using an o-aminobenzamido dianion lanthanide complex, a general mechanism, involving the tandem reaction of two lanthanide-ligand bonds with one heterocumulene molecule, is proposed as well.