59981-63-4

Usage

Chemical Properties

White crystalline powder

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 564, 1984 DOI: 10.1021/jm00371a002

InChI:InChI=1/C7H9N3O2/c11-7(12)5-1-4-6(2-8-5)10-3-9-4/h3,5,8H,1-2H2,(H,9,10)(H,11,12)

Upstream product

• 50-00-0 formaldehyd 
• 71-00-1 L-histidine 
• 71-00-1 L-histidine 

Downstream Products

• 59969-90-3 (S)-5-hydroxymethyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid 
• 156335-71-6 6-(trifluoromethyl)-1H-imidazo<4,5-c>pyridine 
• 133807-90-6 (S)-5-benzoyl-4,5,6,7-tetrahydro-3H-imidazo<4.5-c>pyridine-6-carboxylic acid 
• 114786-39-9 spinacine methyl ester dihydrochloride 
• 133807-88-2 (S)-4,5,6,7-tetrahydro-5-<(phenylamino)carbonyl>-3H-imidazo<4.5-c>pyridine-6-carboxylic acid 

Relevant academic research and scientific papers

NITROGEN-CONTAINING COMPOUND, METHOD FOR MANUFACTURING THE SAME, AND OPTICAL FUNCTIONAL MATERIAL INCLUDING THE SAME

PROBLEM TO BE SOLVED: To provide a novel nitrogen-containing compound having luminescence property. SOLUTION: A nitrogen-containing compound represented by the following formula (I) in which RA, RB, R1, R2, R3, R4, and X are either one of the following (1) and (2). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Hexacyclic piperazinedione compound and preparation, biological activity and application thereof

The invention discloses a hexacyclic piperazinedione compound as shown in the following formula: tetrahydro-beta-carboline [3: 4] piperazine-2, 5-diketopiperidine [4: 5] imidazole. The invention discloses a preparation method and application thereof. The compound not only has an anti-tumor proliferation effect, but also can inhibit migration and invasion of tumor cells, and also has an in-vivo anti-metastasis effect.

Preparation, activity and application of theanine tetrahydroimidazopyridine-6-formylglycine and alanine

The invention discloses a preparation method of (6S)-5-theanine acyl-4, 5, 6, 7-tetrahydro-3H-imidazole [4, 5-c] pyridin-6-formyl AA (AA is glycine residue and L-alanine residue), discloses a preparation method of the compounds, antithrombotic activity of the compounds, thrombolytic activity of the compounds and treatment effect of the compounds on ischemic stroke for 24 hours. Therefore, the invention discloses application of the compounds in preparation of antithrombotic medicines, thrombolytic medicines and medicines for treating ischemic stroke for 24 hours.

DIMETHYL AMINO AZETIDINE AMIDES AS JAK INHIBITORS

The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions compris

Polar amino acid benzyl ester modified spinacin, synthesis, activity evaluation and applications thereof

The invention relates to polar amino acid benzyl ester modified spinacin, synthesis, activity evaluation and applications thereof, and discloses 3H-imidazo[4,5-c]pyridine-6-formyl-[N-(Cl-CH2C=NH)-Orn]-AA-OBzl represented by the following formula (AA is selected from L-Met, L-Asn, L-Arg(NO2), L-Ser, L-Tyr, L-Thr, L-Glu(OBzl), L-Asp(OBzl) and L-Gln residue), a preparation method, tumor growth inhibition effect and anti-inflammatory activity thereof, such that the invention discloses applications of the3H-imidazo[4,5-c]pyridine-6-formyl-[N-(Cl-CH2C=NH)-Orn]-AA-OBzl in preparation of antitumor drugs and anti-inflammatory drugs. The formula is defined in the specification.

Non-polar amino acid benzyl ester modified spinacin, synthesis, activity evaluation and applications thereof

The invention relates to non-polar amino acid benzyl ester modified spinacin, synthesis, activity evaluation and applications thereof, and discloses 3H-imidazo[4,5-c]pyridine-6-formyl-[N-(Cl-CH2C=NH)-Orn]-AA-OBzl represented by the following formula (AA is selected from L-Pro, Gly, L-Ala, L-Phe, L-Ile, L-Leu, L-Val and L-Trp), a preparation method, tumor growth inhibition effect and anti-inflammatory activity thereof, such that the invention discloses applications of the3H-imidazo[4,5-c]pyridine-6-formyl-[N-(Cl-CH2C=NH)-Orn]-AA-OBzl in preparation of antitumor drugs and anti-inflammatory drugs. The formula is defined in the specification.

Synthesis of 4,7,8a,9-tetrahydro-3h-diimidazo-[1,5-a:4′,5′-d]pyridine derivatives

The synthesis and evaluation of new ligands for the H3 receptor of histamine is described. These new compounds are diimidazopyridine derivatives readily prepared by a condensation reaction of spinacine and isocyanates.