59997-19-2

Basic information

• Product Name: 10-butylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
• CAS NO: 59997-19-2
• Molecular Formula: C₁₅H₁₅N₃O₂
• Molecular Weight: 269.2985
• Mol File: 59997-19-2.mol
• Article Data: 3

Chemical Properties

• Density: 1.33g/cm³
• Refractive Index: 1.669
• CAS DataBase Reference: 10-butylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 10-butylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione(59997-19-2)
• EPA Substance Registry System: 10-butylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione(59997-19-2)

Safety Data

• Hazardous Substances Data: 59997-19-2(Hazardous Substances Data)

Usage

Chemical structure

Quinoline derivative with a fused pyrimidine ring

Antitumor agent

Inhibits the growth of cancer cells

Antimicrobial drug

Exhibits antibacterial and antifungal activities

Treatment of neurodegenerative diseases

Inhibits aggregation of amyloid-beta protein associated with Alzheimer's disease

Ongoing research

Further investigation into its therapeutic properties for various biomedical applications

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 28484-86-8 6-butylaminouracil 
• 6630-33-7 ortho-bromobenzaldehyde 
• 89-98-5 2-chloro-benzaldehyde 

Relevant articles and documents

Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine under anaerobic conditions by reductively activated nitro 5-deazaflavin derivatives

Electrolytically reduced 6- and 8-nitro-5-deazaflavin derivatives have been found to interact to react specifically with guanine base by means of cyclic voltammetry. Electrolytic reductions of 6- and 8-nitro-5-deazaflavin derivatives in the presence of the 2'-deoxyguanosine under anaerobic conditions resulted in prominent formation of 8-oxo-7,8-dihydro-2'- deoxyguanosine.

A New, General, and Convenient Synthesis of 5-Deazaflavins (5-Deazaisoalloxazines) and Bis-(5-deazaflavin-10-yl)alkanes

The condensation of 6-substituted aminouracils or bis(uracil-6-amino)alkanes with o-halogenobenzaldehydes in dimethylformamide led to the formation of the corresponding 5-deazaflavins or bid(5-deazaflavin-10-yl)alkanes in a single step.