60-70-8 Usage
Uses
Used in Pharmaceutical Industry:
Veratramine is used as a signal transduction inhibitor for treating tumors. It inhibits the Hedgehog (Hh) signaling pathway, which plays a crucial role in morphogenesis and has potential applications in cancer treatment. Veratramine can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM, making it a promising candidate for cancer therapy.
Used in Cardiovascular Applications:
Veratramine has anti-thrombotic activity, as it dose-dependently inhibits platelet aggregation in rabbits ex vivo. This property makes it potentially useful in the development of treatments for thrombotic disorders and related cardiovascular conditions.
Used in Central Nervous System (CNS) Applications:
Veratramine induces serotonin release and inhibits its re-uptake in the CNS. This dual action suggests potential applications in the treatment of neurological and psychiatric disorders, particularly those involving serotonin dysregulation, such as depression and anxiety.
References
Saito., Bull. Chem. Soc., Japan, 15, 22 (1940)
Jacobs, Craig.,J. Biol. Chem., 155,565 (1944)
Jacobs,.Craig., ibid, 160,555 (1945)
Tamm, Wintersteiner., J. Amer. Chem. Soc., 74,3842 (1952)
Mass spectra:
Budzikiwicz., Tetrahedron, 20,2267 (1964)
Synthesis:
Masamune, Takasugi, Murai., Tetrahedron, 27,3369 (1971)
Check Digit Verification of cas no
The CAS Registry Mumber 60-70-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 0 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 60-70:
(4*6)+(3*0)+(2*7)+(1*0)=38
38 % 10 = 8
So 60-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H39NO2/c1-15-11-25(30)26(28-14-15)17(3)20-7-8-21-22-6-5-18-12-19(29)9-10-27(18,4)24(22)13-23(21)16(20)2/h5,7-8,15,17,19,22,24-26,28-30H,6,9-14H2,1-4H3
60-70-8Relevant academic research and scientific papers
Isolation of Cyclopamine
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Paragraph 0115; 0117, (2016/07/05)
Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.
