6000-17-5Relevant academic research and scientific papers
Total synthesis of 3-hydroxy-6-oxaestra-1,3,5(10)-trien-17-one
Cao, Zhisong,Liehr, Joachim G.
, p. 841 - 844 (1996)
The modified steroid estrogen, 3-hydroxy-6-oxaestra-1,3,5(10)-trien-17-one, i.e. 6-oxaestrone 8 has been prepared from 7-methoxychromanone 1 by de novo synthesis of the modified steroid ring system. The 1H and 13C NMR data for the intermediate products 3, 4, 4a, 4b, 4c, 6, 7, and for the final product 8 support the proposed structures. A mechanism for the ring-closure reaction of 3 to intermediate products 4 and 4a is proposed.
Synthesis of 6-oxaestra-1,3,5(10),8,14-pentaenes
Abusalimov,Nikol'skaya,Starova,Selivanov,Shavva
, p. 42 - 47 (2007/10/03)
The Wendler version of the Torgov-Ananchenko scheme of total steroid synthesis was shown to be applicable to the preparation of 6-oxaestra-1,3.5(10), 8,14-pentaenes. Conditions for cyclodehydration of secosteroids thus obtained were found, which ensured i
