60000-15-9Relevant academic research and scientific papers
Radical Capture at Nickel(II) Complexes: C-C, C-N, and C-O Bond Formation
Bakhoda, Abolghasem Gus,Bertke, Jeffery A.,Figula, Bryan C.,Greene, Christine,Warren, Timothy H.,Wiese, Stefan
, p. 1710 - 1718 (2020)
The dinuclear β-diketiminato NiII tert-butoxide {[Me3NN]Ni}2(μ-OtBu)2 (2), synthesized from [Me3NN]Ni(2,4-lutidine) (1) and di-tert-butylperoxide, is a versatile precursor for the synthesis of a series of NiII complexes [Me3NN]Ni-FG (FG = functional group) to illustrate C-C, C-N, and C-O bond formation at NiII via radical capture. {[Me3NN]Ni}2(μ-OtBu)2 reacts with nitromethane, alkyl and aryl amines, acetophenone, benzamide, ammonia, and phenols to deliver the corresponding mono- or dinuclear [Me3NN]Ni-FG species (FG = O2NCH2, R-NH, ArNH, PhC(O)NH, PhC(O)CH2, NH2, and OAr). Many of these NiII complexes are capable of capturing the benzylic radical PhCH(?)CH3 to deliver the corresponding PhCH(FG)CH3 products featuring C-C, C-N, or C-O bonds. Density functional theory studies shed light on the mechanism of these transformations and suggest two competing pathways that depend on the nature of the functional groups. These radical capture reactions at [NiII]-FG complexes outline key C-C, C-N, and C-O bond forming steps, foreshadowing families of nickel radical relay catalysts.
Catalytic C - H amination with unactivated amines through copper(II) amides
Wiese, Stefan,Badiei, Yosra M.,Gephart, Raymond T.,Mossin, Susanne,Varonka, Matthew S.,Melzer, Marie M.,Meyer, Karsten,Cundari, Thomas R.,Warren, Timothy H.
supporting information; experimental part, p. 8850 - 8855 (2011/02/24)
En route to catalysis: Two equivalents of the three-coordinate copper(II) amide [(Cl2NN)Cu]-NHAd participate in stoichiometric C - H amination by a H-atom abstraction/radical capture sequence. This active species may be generated through a copper(II) tert-butoxide intermediate to allow for the unprecedented catalytic amination of sp3-C - H bonds with unactivated alkylamines. This method greatly expands the range of amines for catalytic C - H amination since most protocols require N-based electron-withdrawing groups.
The N-Substitution of Aliphatic Primary Amines via 1-benzotriazoles: Preparation of Secondary Amines
Katritzky, Alan R.,Glen, Noble,Pilarski, Boguslaw,Harris, Philip
, p. 1443 - 1446 (2007/10/02)
A new method has been developed for the selective conversion of primary aliphatic amines into unsymmetrical secondary amines by Grignard reaction of 1-benzotriazoles 1.This method employs simple procedures and mild conditions, and is specific in that onyl monoalkylation of the primary amines results.
