60011-04-3

Usage

Piperidine derivative

The compound contains a piperidine ring, which is a six-membered nitrogen-containing ring, and has a diphenyl substituent and an acetic acid moiety attached to it.
药用化学中的潜在药物候选物：2-(2-Oxo-3,3-diphenylpiperidin-1-yl)acetic acid在药用化学中被用作各种治疗应用的潜在药物候选物，包括作为镇痛剂和抗精神病药。
研究和开发新药的潜力：该化合物也可能在研究和开发针对神经系统和精神障碍的新药物方面具有潜力。
作为合成其他具有类似化学结构和生物活性的有机化合物的前体或中间体的潜力：该化合物也可以用作合成其他具有类似化学结构和生物活性的有机化合物的前体或中间体。

Upstream product

• 3469-00-9 methyl 2,2-diphenylacetate 
• 2997-24-2 Ethyl 4-cyano-2,2-diphenylbutanoate 
• 3468-99-3 ethyl diphenylacetate 
• 117-34-0 2,2-diphenylacetic acid 
• 24056-59-5 3,3-Diphenylpiperidin-2-one 
• 1219624-63-1 ethyl 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetate 

Downstream Products

• 1219624-66-4 1-[2-(3,3-diphenylpiperidin-1-yl)-2-oxoethyl]-3,3-diphenylpiperidin-2-one 
• 1219624-69-7 1-{2-[2-(4-fluorophenyl)piperidin-1-yl]-2-oxoethyl}-3,3-diphenylpiperidin-2-one 
• 1219624-79-9 1-[2-oxo-2-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)ethyl]-3,3-diphenylpiperidin-2-one 
• 1219625-10-1 3,3-diphenyl-1-({3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)piperidin-2-one 
• 1219626-56-8 1-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl}methyl)-3,3-diphenylpiperidin-2-one 
• 1219626-36-4 3,3-diphenyl-1-({3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}methyl)piperidin-2-one 
• 1219625-79-2 1-{2-[4-(4-chlorophenoxy)piperidin-1-yl]-2-oxoethyl}-3,3-diphenylpiperidin-2-one 
• 1334536-61-6 2-(2-oxo-3,3-diphenylpiperidin-1-yl)-N-piperidin-4-ylacetamide 
• 1334536-84-3 tert-butyl 4-(2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetamido)piperidine-1-carboxylate 
• 1334536-62-7 3,3-dimethyl-4-[(2-oxo-3,3-diphenylpiperidin-1-yl)acetyl]piperazin-2-one 
• 1219626-07-9 3,3-diphenyl-1-({3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)piperidin-2-one 
• 1219625-71-4 1-{[3-(1H-indazol-5-yl)-1,2,4-oxadiazol-5-yl]methyl}-3,3-diphenylpiperidin-2-one 
• 1219626-46-6 1-{[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}-3,3-diphenylpiperidin-2-one 
• 1219626-48-8 1-{[3-(4-chlorobenzyl)-1,2,4-oxadiazol-5-yl]methyl}-3,3-diphenylpiperidin-2-one 

Relevant academic research and scientific papers

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

A novel series of diphenyl lactam containing calcium channel blockers is described. Extensive SAR studies resulted in compounds with low molar activity and good plasma exposure after oral dosing. Compounds 2, 6 and 7 demonstrated significant efficacy in the capsaicin model of secondary hyperalgesia following oral administration.

LACTAM ACETAMIDES AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, n, R1, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.