600136-09-2 Usage
General Description
3-HYDROXYMETHYL-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C15H19NO4. It is a tert-butyl ester derivative of 3-hydroxymethyl-5-methoxyindole-1-carboxylic acid, which is a key intermediate in the synthesis of bioactive molecules and pharmaceutical compounds. This chemical is commonly used in research and development for the synthesis of new drug candidates and in the study of indole-based compounds for their potential pharmacological properties. It is important to handle this chemical with caution and adhere to proper safety protocols due to its potential hazardous properties.
Check Digit Verification of cas no
The CAS Registry Mumber 600136-09-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,0,1,3 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 600136-09:
(8*6)+(7*0)+(6*0)+(5*1)+(4*3)+(3*6)+(2*0)+(1*9)=92
92 % 10 = 2
So 600136-09-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H19NO4/c1-15(2,3)20-14(18)16-8-10(9-17)12-7-11(19-4)5-6-13(12)16/h5-8,17H,9H2,1-4H3
600136-09-2Relevant articles and documents
Asymmetric Total Synthesis of Sarpagine and Koumine Alkaloids
He, Ling,Jiang, Yan,Qiao, Zhen,Qiu, Hanyue,Su, Xiaojiao,Tan, Qiuyuan,Yang, Jiaojiao,Yang, Zhao,Zhang, Min,Zhou, Wenqiang
, p. 13105 - 13111 (2021/05/10)
We report here a concise, collective, and asymmetric total synthesis of sarpagine alkaloids and biogenetically related koumine alkaloids, which structurally feature a rigid cage scaffold, with L-tryptophan as the starting material. Two key bridged skeleton-forming reactions, namely tandem sequential oxidative cyclopropanol ring-opening cyclization and ketone α-allenylation, ensure concurrent assembly of the caged sarpagine scaffold and installation of requisite derivative handles. With a common caged intermediate as the branch point, by taking advantage of ketone and allene groups therein, total synthesis of five sarpagine alkaloids (affinisine, normacusine B, trinervine, Na-methyl-16-epipericyclivine, and vellosimine) with various substituents and three koumine alkaloids (koumine, koumimine, and N-demethylkoumine) with more complex cage scaffolds has been accomplished.
