600144-27-2Relevant academic research and scientific papers
The traceless Staudinger ligation for indirect 18F- radiolabelling
Carroll, Laurence,Boldon, Sophie,Bejot, Romain,Moore, Jane E.,Declerck, Jerome,Gouverneur, Veronique
supporting information; experimental part, p. 136 - 140 (2011/02/23)
The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger
PREPARATION OF LABELLED COMPOUNDS
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Page/Page column 97-98, (2010/12/18)
The invention relates to a process for producing a labelled compound, which process comprises treating a compound of formula (I), wherein X is a moiety to be labelled or a detectable label, and R1, R2, R3 and R4 are substitutent groups as defined herein; with a compound of formula (II) : N3-L-Y (π) wherein Y is a detectable label or a moiety to be labelled, provided that if X in the compound of formula (I) is a moiety to be labelled, then Y is a detectable label and if X in the compound of formula (I) is a detectable label, then Y is a moiety to be labelled; and L is a bond or a linking group, thereby producing a labelled compound of formula (IH) by Staudinger Ligation. Groups R3 and R4 may comprise fluorous moieties, in order to facilitate purification of the labelled compound of formula (IH). The invention also provides methods of imaging a human or non-human patient or a cell or in vitro sample, using the labelled compound of formula (III) thus produced, as well as imaging methods in which the compounds of formulae (I) and (II) are administered to the patient, cell or sample. The invention further provides novel compounds of formula (I) and formula (III), a process for producing the compounds of formula (T), and a combination product for medical imaging comprising a compound of formula (I) and a compound of formula (II).
A new regioselective Heck vinylation with enamides. Synthesis and investigation of fluorous-tagged bidentate ligands for fast separation
Vallin, Karl S. A.,Zhang, Qisheng,Larhed, Mats,Curran, Dennis P.,Hallberg, Anders
, p. 6639 - 6645 (2007/10/03)
Internal ligand-controlled Heck vinylations of enamides were performed with high regioselectivity and delivered moderate to good yields of dienamides. Controlled heating by microwave irradiation accelerated the palladium-catalyzed reactions, and full conv
