600151-65-3Relevant academic research and scientific papers
Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives
Dofe, Vidya S.,Sarkate, Aniket P.,Shaikh, Zarina M.,Gill, Charansingh H.
, p. 59 - 65 (2018/01/18)
New tetrazole-based pyrazole and pyrimidine derivatives were synthesized by an ultrasound irradiation method. All compounds were characterized by infrared spectroscopy (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectrometry (MS) and elemental analysis and assessed in vitro for their efficacy as antimicrobial agents against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus Niger). Compounds 8a, 8e, 9a, 9b and 9e show potent activity against the tested strains compared to the reference drugs chloramphenicol and clotrimazole.
Synthesis, antimicrobial activity and anti-biofilm activity of novel tetrazole derivatives
Dofe, Vidya S.,Sarkate, Aniket P.,Kathwate, Santosh H.,Gill, Charansingh H.
, p. 325 - 330 (2017/08/18)
In the development of antimicrobial agents, we designed and synthesized novel tetrazole derivatives. The structures of compounds 6a-f and 7a-f were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. These compounds were tested for their antimicrobial activity against a series of strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and for antifungal activity against the strains Candida albicans, Candida glabrata, and Candida tropicalis. Compounds 6e, 6f, 7a, and 7f exhibit potent antimicrobial activities compared to the reference drugs streptomycin and miconazole. Tetrazole derivatives 7a-f also inhibit biofilm formation and compound 7f exhibits best anti-biofilm activity with a biofilm inhibitory concentration (BIC) as low as 0.9 μm.
Ultrasound-Mediated Synthesis of Novel 1,2,3-Triazole-Based Pyrazole and Pyrimidine Derivatives as Antimicrobial Agents
Dofe, Vidya S.,Sarkate, Aniket P.,Shaikh, Zarina M.,Gill, Charansingh H.
, p. 3195 - 3201 (2017/10/06)
In the development of novel antimicrobial agents, we synthesized novel 1,2,3-triazole-based pyrazole and pyrimidine derivatives 6(a–f) and 7(a–f) by ultrasound-assisted method. The synthesized compounds were characterized by IR, 1H NMR, 13
Novel O-Alkylated Chromones as Antimicrobial Agents: Ultrasound Mediated Synthesis, Molecular Docking and ADME Prediction
Dofe, Vidya S.,Sarkate, Aniket P.,Lokwani, Deepak K.,Shinde, Devanand B.,Kathwate, Santosh H.,Gill, Charansing H.
, p. 2678 - 2685 (2017/09/25)
In the development of novel antimicrobial agents, we synthesized novel O-alkylated chromones 4a–f by ultrasound-assisted method. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS, and elemental analysis. All com
Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles
Dofe, Vidya S.,Sarkate, Aniket P.,Lokwani, Deepak K.,Kathwate, Santosh H.,Gill, Charansingh H.
, p. 15 - 28 (2017/01/14)
Abstract: In Search of novel antimicrobial agents with improved potency, we designed and synthesized a series of 3-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)-2-(4-fluorophenyl)-4H-chromen-4-ones 5a–f using click chemistry. The structures of synthesized com
Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid
Gobbi, Silvia,Rampa, Angela,Bisi, Alessandra,Belluti, Federica,Piazzi, Lorna,Valenti, Piero,Caputo, Anna,Zampiron, Antonella,Carrara, Maria
, p. 3662 - 3669 (2007/10/03)
New analogues of flavone-8-acetic acid were synthesized, bearing an alkoxy group in position 3 and different substituents on the benzene ring in position 2 of the flavone nucleus. The compounds were tested for direct cytotoxicity against four human tumor cell lines and for indirect antitumor effects by measuring their ability to enhance lytic properties of murine macrophages and human monocytes. Though direct toxicity was very low, the compounds were able to induce significant indirect toxicity. Notably, most of them (4c, 4d, 4e, 4f, 4h, 4i, 4m, 4n, and 4o) showed important activity on human monocytes and could be regarded as the first flavone derivatives endowed with such activity. Particularly interesting seem to be compounds 4m and 4n, which showed IC 50 values up to 7 times higher than DMXAA, which has now completed phase I clinical trials.
