600153-25-1

Upstream product

• 1530777-90-2 tert-butyl 20-(tosyloxy)-3,6,9,12,15,18-hexaoxicosanoate 
• 297162-50-6 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester 
• 86123-10-6 Fmoc-D-Phe-OH 
• 600153-12-6 N-α-Fmoc-N-β-(N-tert-butyloxycarbonylaminooxyacetal)-L-diaminopropionic acid 
• 437655-96-4 20-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18-hexaoxaeicosanoic acid 

Relevant academic research and scientific papers

Multimeric cyclic RGD peptides as potential tools for tumor targeting: Solid-phase peptide synthesis and chemoselective oxime ligation

The αvβ3 integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Targeting this receptor may provide information about the receptor status of the tumor and enable specific therapeutic planning. Solid-phase peptide synthesis of multimeric cyclo(-RGDfE-)-peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects. These peptides contain an aminooxy group for versatile chemoselective oxime ligation. Conjugation with para-trimethylstannylbenzaldehyde results in a precursor for radioiododestannylation, which would allow them to be used as potential tools for targeting and imaging αvβ3-expressing tumor cells. The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions.