600173-06-6Relevant academic research and scientific papers
Enantioselective cyanoformylation of aldehydes catalyzed by a chiral quaternary ammonium salt and triethylamine
Peng, Dan,Zhou, Hui,Liu, Xiaohua,Wang, Liwei,Chen, Shikui,Feng, Xiaoming
, p. 2448 - 2450 (2007)
An efficient enantioselective cyanoformylation of aldehydes with ethyl cyanoformate, catalyzed by a chiral quaternary ammonium salt and triethylamine, has been developed. The reaction can be carried out in excellent yields (up to 97%) with moderate enanti
N-heterocyclic carbene catalyzed cyanation reaction of carbonyl compounds with ethyl cyanoformate and acetyl cyanide
Zhang, Jie,Du, Guangfen,Xu, Yueke,He, Lin,Dai, Bin
supporting information; experimental part, p. 7153 - 7156 (2012/01/05)
N-heterocyclic carbene (NHC) has been employed as an efficient catalyst for cyanation reaction of carbonyl compounds. Under catalysis of 1 mol % NHCs, various aldehydes and 2,2,2-trifluoroacetophenone coupled with ethyl cyanoformate in THF to provide cyanohydrins ethyl carbonates in excellent yields. While in the presence of 10 mol % catalyst, different types of aldehydes and 2,2,2-trifluoroacetophenone reacted with acetyl cyanide in dichloroethane to give acylated cyanohydrins in moderate to high yields.
Ionic liquid as catalytic and reusable media for cyanoethoxycarbonylation of aldehydes
Khan, Noor-Ul H.,Agrawal, Santosh,Kureshy, Rukhsana I.,Abdi, Sayed H.R.,Sadhukhan, Arghya,Pillai, Renjith S.,Bajaj, Hari C.
experimental part, p. 907 - 912 (2010/10/03)
Various ionic liquids (IL 1-9) based on N-methyl N'-alkyl imidazolium salts were explored as catalytic media in cyanoethoxycarbonylation of various aldehydes. The study revealed that the alkyl chain length and counter ion of the ionic liquid are critical
N,N-Dimethylpyridin-4-Amine mediated protocol for cyanoethoxycarbonylation of aldehydes under solvent-free conditions
Khan, Noor-Ul H.,Agrawal, Santosh,Kureshy, Rukhsana I.,Bera, Prasanta K.,Abdi, Sayed H.R.,Bajaj, Hari C.
experimental part, p. 255 - 260 (2010/11/05)
N,N-Dimethylpyridin-4-amine(DAMP)(10 mol%) was successfully employed as catalyst for cyanoethoxycarbonylation of aromatic and aliphatic aldehydes at room temperature under solvent free condition to give corresponding ethylcyanocarbonates in excellent isol
Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters
Thasana, Nopporn,Prachyawarakorn, Vilailak,Tontoolarug, Sopchok,Ruchirawat, Somsak
, p. 1019 - 1021 (2007/10/03)
A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leading to 2-phenylbenzofuran-3-carboxylic acid.
