600179-41-7Relevant academic research and scientific papers
Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs
Burke, Philip J.,Wong, Lai Chun,Jenkins, Terence C.,Knox, Richard J.,Meikle, Ian T.,Stanforth, Stephen P.
supporting information, p. 5851 - 5854 (2016/12/06)
A series of N-nitroarylated-3-chloromethyl-1,2,3,4-tetrahydroisoquinoline derivatives, several of which also possessed a trifluoromethyl substituent, were prepared and assessed as potential nitroaromatic prodrugs. The enzymatic reduction of these compound
Synthesis of tri- and tetracyclic condensed quinoxalin-2-ones fused across the C-3 - N-4 bond
Chicharro, Roberto,De Castro, Sonia,Reino, Jose L.,Aran, Vicente J.
, p. 2314 - 2326 (2007/10/03)
We have studied the preparation of some fused quinoxalinones by Stevens rearrangement of a spiro-quinoxaline-derived ammonium ylide or by treatment of N-(2,4-dinitrophenyl)-and N-(2-nitrophenyl)imino acids with different reducing agents. We have reinvestigated and clarified some related processes found in the literature starting from imino acids derivatives. Additional reactions of the fused quinoxalinones, as well as the useful dehydrogenation/decarboxylation of some easily available 1-arylindoline-2-carboxylic acids to the corresponding 1-arylindoles, are also reported. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
